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EC number: 627-132-7 | CAS number: 1227096-04-9
Individual scores for eye irritation:
Mean scores calculated for each animal over 24, 48 and 72 hours were (0.3) (0.7) and (0) for chemosis, (0.7) (1) and (0.3) for redness of the conjunctivae, (0) (0) and (0) for iris lesions and (0) (0) and (0) for corneal opacity.
The potential of Genamin SH 301 to induce eye irritation was assessed in 3 rabbits according to the OECD guideline 405 and in compliance with the principles of Good Laboratory Practice regulations.
A single dose of 0.1ml of the test item was instilled into one eye, the other eye was not treated and served as control. The eyes were not rinsed after administration of the test item.
Mean scores calculated over 24, 48 and 72 hours for the 3 animals were 0.3 for chemosis, 0.7 for redness of the conjunctiva, 0 for iris lesions and 0 for corneal opacity. Redness and chemosis were fully reversible within 72 hours.
Under these experimental conditions, Genamin SH 301 was considered non- irritant when administered by ocular route to rabbits.
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