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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
not specified
GLP compliance:
not specified
Type of method:
column elution method
Key result
Water solubility:
ca. 6 mg/L
Temp.:
25 °C
Remarks on result:
other: The above value correponds to DPHA.
Key result
Water solubility:
ca. 80 mg/L
Temp.:
25 °C
Remarks on result:
other: The above value correponds to DPPA.
Details on results:
The water solubility was also calculated from log Pow or log Kow due to the CAS number or chemical structure of DPHA.

Experimental values:

Sample #

DPPA Water solubility (experimental) (mg/L)

DPHA Water solubility (experimental) (mg/L)

DPHA

80

6

 

Calculated value:

DPHA

Water solubility

experimental

HPLC-UV

Water solubility estimation

(WSKOW v1.42)

Water solubility estimation

(WATERNT v1.01 est)

DPHA

6 mg/L (25°C)

0.5 mg/L (25°C)

1.7 mg/L (25°C)

DPPA

80 mg/L (25°C)

48.2 mg/L (25°C)

113.6 mg/L (25°C)

 

Conclusions:
Under the study conditions, the water solubility of the test substance (lowest water solubility value of main constituent of DPHA) was considered to be 6 mg/L.
Executive summary:

A study was conducted to determine the water solubility of test substance, DPHA according to the OECD Guideline 105, using column elution method. DPHA is a multi constituent product. The water solubility of DPPA is 80 mg/L and water solubility of DPHA is 6 mg/L. Hence, the test substance is slightly soluble in water. The lowest water solubility value was selected to represent the substance as this is equivalent to the worst case from an environmental perspective (slightly lower biodegradation and higher Henry’s constant). Also, it is the value for the main constituent, DPHA. Under the study conditions, the water solubility of the test substance (lowest water solubility value of main constituent of DPHA) was considered to be 6 mg/L (Herssens, 2010).

Description of key information

The water solubility of the test substance was determined according to OECD Guideline 105, using the column elution method (Herssens, 2010). 

Key value for chemical safety assessment

Water solubility:
6 mg/L
at the temperature of:
25 °C

Additional information

The lowest water solubility value was selected to represent the substance as this is equivalent to the worst case from an environmental perspective (slightly lower biodegradation and higher Henry’s constant). Also, it is the value for the main constituent, DPHA.