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EC number: 204-662-3 | CAS number: 123-92-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
LD50 Rabbit oral = 7400 mg/kg (HSDB: [American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, 1991., p. 810])
LD50 rat oral = 16600 mg/kg (NIOSH (http://www.cdc.gov/niosh-rtecs/ns958940.html): Yakkyoku, 32, 1241-47, 1981, Nanzando, Tokyo, ISSN: 0044-0035)
LD50 rabbit oral (Munch, J.C., Industrial medicine and surgery, Vol. 41, Nr. 4, 31-33, 19):
- ND50: 32 mmol/kg (= 4160 mg/kg; calculated with a molar mass of 130)
- LD50: 57 mmol/kg (= 7410 mg/kg; calculated with a molar mass of 130)
Acute dermal toxicity (review: OPDYKE D L J, FOOD COSMET TOXICOL, 13 (5), 545-554, 1975. original source mentioned: Moreno, O.M. (1973). Report to RIFM, 1 February.):
- LD50 rabbit > 5 g/kg
Acute inhalation toxicity:
Acute toxicity of "i-Amylacetat" to the cat, deep narcosis after 75 and 85 min at 56 mg/l in the air and after 110 and 105 min at 51 mg/l (replicates determined respectively). Ferdinand Flury und Wolfgang Wirth, International Archives of Occupational and Environmental Health Springer Berlin / Heidelberg ISSN 0340-0131 (Print), Heft Volume 5, Number 1, Seiten 1-90, Dezember 1933, DOI 10.1007/BF02274996
Acute toxicity other routes:
LD50 guinea pig (one animal), Applied dose subcutaneous per body weight of animal (g/kg): 5
After 1/2 hour deep narcosis, thereafter rear extremities paralysed. Death after 6 days.
Ferdinand Flury und Wolfgang Wirth, International Archives of Occupational and Environmental Health Springer Berlin / Heidelberg ISSN 0340-0131 (Print), Heft Volume 5, Number 1, Seiten 1-90, Dezember 1933, DOI 10.1007/BF02274996
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 7 400 mg/kg bw
Additional information
The data about acute oral toxicity appears most reliable. Accreditation of HSDB in respect of data reliability is given. Furthermore the value of 7400 mg/kg (LD50) is indicated by two data sources. It does not appear essential to deliver data on the inhalative acute toxicity (LC50) and the dermal acute toxicity (LD50) due to low oral acute toxicity value (LD50).
Justification for classification or non-classification
The oral LD50 of 7400 mg/kg bw was well above 2000 mg/kg bw. An oral LD50 of 300-2000 mg/kg bw would have led to a classification into the least stringent of four acute toxicity categories.
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