Isopentyl acetate

Endpoint summary

Description of key information

Acute oral toxicity:

LD50 Rabbit oral = 7400 mg/kg (HSDB: [American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, 1991., p. 810])

LD50 rat oral = 16600 mg/kg (NIOSH (http://www.cdc.gov/niosh-rtecs/ns958940.html): Yakkyoku, 32, 1241-47, 1981, Nanzando, Tokyo, ISSN: 0044-0035)

LD50 rabbit oral (Munch, J.C., Industrial medicine and surgery, Vol. 41, Nr. 4, 31-33, 19):

- ND50: 32 mmol/kg (= 4160 mg/kg; calculated with a molar mass of 130)

- LD50: 57 mmol/kg (= 7410 mg/kg; calculated with a molar mass of 130)

Acute dermal toxicity (review: OPDYKE D L J, FOOD COSMET TOXICOL, 13 (5), 545-554, 1975. original source mentioned: Moreno, O.M. (1973). Report to RIFM, 1 February.):

- LD50 rabbit > 5 g/kg

Acute inhalation toxicity:

Acute toxicity of "i-Amylacetat" to the cat, deep narcosis after 75 and 85 min at 56 mg/l in the air and after 110 and 105 min at 51 mg/l (replicates determined respectively). Ferdinand Flury und Wolfgang Wirth,  International Archives of Occupational and Environmental Health Springer Berlin / Heidelberg  ISSN 0340-0131 (Print), Heft Volume 5, Number 1, Seiten 1-90, Dezember 1933, DOI 10.1007/BF02274996

Acute toxicity other routes:

LD50 guinea pig (one animal), Applied dose subcutaneous per body weight of animal (g/kg): 5

After 1/2 hour deep narcosis, thereafter rear extremities paralysed. Death after 6 days. 

Ferdinand Flury und Wolfgang Wirth,  International Archives of Occupational and Environmental Health Springer Berlin / Heidelberg  ISSN 0340-0131 (Print), Heft Volume 5, Number 1, Seiten 1-90, Dezember 1933, DOI 10.1007/BF02274996

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

Value:

7 400 mg/kg bw

Additional information

The data about acute oral toxicity appears most reliable. Accreditation of HSDB in respect of data reliability is given. Furthermore the value of 7400 mg/kg (LD50) is indicated by two data sources. It does not appear essential to deliver data on the inhalative acute toxicity (LC50) and the dermal acute toxicity (LD50) due to low oral acute toxicity value (LD50).

Justification for classification or non-classification

The oral LD50 of 7400 mg/kg bw was well above 2000 mg/kg bw. An oral LD50 of 300-2000 mg/kg bw would have led to a classification into the least stringent of four acute toxicity categories.