Registration Dossier
Registration Dossier
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EC number: 204-662-3 | CAS number: 123-92-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Details on methodology are given. Large number of animals used (ca. 100). This data is probably the basis for the HSDB entry, see under 7.3.1.001, as the result is the same oral LD50 (rabbit). That HSDB entry is **PEER REVIEWED**
Data source
Reference
- Reference Type:
- publication
- Title:
- Aliphatic alcohols and alkyl esters: Narcotic and lethal potencies to tadpoles and to rabbits.
- Author:
- Munch
- Year:
- 1 972
- Bibliographic source:
- Industrial Medicine and Surgery, 41(4), 31-33
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Saline solution used to wash down the test substance through a catheter into the stomach of rabbits. Observation follows. Determination of the narcotic and lethal dose for 50 % of the test animals.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Isopentyl acetate
- EC Number:
- 204-662-3
- EC Name:
- Isopentyl acetate
- Cas Number:
- 123-92-2
- Molecular formula:
- C7H14O2
- IUPAC Name:
- 3-methylbutan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): "Isoamyl Acetate"
Constituent 1
Test animals
- Species:
- rabbit
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: oral with catheter
- Vehicle:
- other: saline solution to wash down substance
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 7 410 mg/kg bw
Any other information on results incl. tables
Results:
Larger doses caused disappearance of corneal reflexes, nystagmus, dyspnea and bradycardia.
ND50: 32 mmol/kg (= 4160 mg/kg; calculated with a molar mass of 130)
LD50: 57 mmol/kg (= 7410 mg/kg; calculated with a molar mass of 130)
Therapeutic index (LD50/ND50): 1.8
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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