Isopentyl acetate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

disregarded due to major methodological deficiencies

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Deficiencies in details about tested material and methodology. The study is not performed according to an acknowledged standard method.

Data source

Reference

Reference Type:

publication

Title:

Zur toxikologie der lösungsmittel

Author:

Ferdinand Flury und Wolfgang Wirth

Year:

1933

Bibliographic source:

International Archives of Occupational and Environmental Health Springer Berlin / Heidelberg ISSN 0340-0131 (Print), Heft Volume 5, Number 1, Seiten 1-90, Dezember 1933, DOI 10.1007/BF02274996

Materials and methods

Principles of method if other than guideline:

exposure of cats to "i-Amylacetat" at constant concentrations up to 56 mg/l via inhalation in a flow through apparatus, followed by investigations of effects: effects on behaviour and narcotic effects, effects on eyes and saliva production, food consumption, body temperature, protein content in urine, diarrhoea

GLP compliance:

no

Test animals

Species:

cat

Sex:

male/female

Administration / exposure

Route of administration:

other: "streaming gas mixture"

Type of inhalation exposure:

whole body

Vehicle:

air

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

other: LOAEL

Effect level:

11 600 mg/m³ air

Remarks on result:

other: 2 animals (cat), in both animals increase of tear fluid production, in the beginning increase of saliva production. 

Any other information on results incl. tables

Results:

The limit concentration that led to narcosis after 6 hours exposure time (inhalation) was 24 mg/l. In the following table the results are laid out.

Trial	Animal	Sex of animal	Conc. test substance in air	Effect on behaviour during exposure				Behaviour/effects after the trial
Trial Nr. (a and b are animals at the same time)	body weight (kg)	(m or f)	(mg/l)	disturbance of equilibrium after ... min	remaining lied down after ... min	deep narcosis after ... min	other symptoms
1a	2.2	m	11.6	/	/	/	in both animals increase of tear fluid production, in the beginning increase of saliva production	in both animals no particular after effects
1b	2.5	m	11.6	/	/	/
2a	3.2	m	12.6	/	/	/	in both animals increase of tear fluid production, in the beginning strong increase of saliva production	both animals eat immediately after treatment, no particular after effects
2b	3.2	m	12.6	/	/	/
3a	2.8	m	15.4	335	/	/	in both animals increase of tear fluid production, in the beginning strong increase of saliva production	both animals eat immediately after treatment, no particular after effects
3b	3.3	m	15.4	335	/	/
4a	2.2	f	15.4	368	423	493	in both animals strong saliva production and tear fluid production. Animal "a" vomits after 420 min	"a" within 15 min excitement of reflexes possible, not at full conscience in the following days. Death after 6 days. Examination of body: lungs hyperaemic and found infested by parasites, death not deemed to be directly related to exposure to test substance. "b" recovers after one hour and survives without particular after effects. Rectal temperature, before treatment: "a" 38.4 °C, "b" 38.3 °C, after treatment: "a" 35.1 °C, "b" 37.2 °C
4b	2.2	f	15.4	368	/	/
5a	2.1	m	23.7	105	225	305	both animals: strong saliva production and tear fluid production. "a" shows clonic spasm after 235 min	in both animals excitement of reflexes possible within 1/2 hour. In the following 2 days both not at full conscience. "a" vomiting several times, surviving. Rectal temperature, before treatment: "a" 38.2 °C, "b" 37.9 °C, after treatment: "a" 35.0 °C, "b" 35.0 °C
5b	2.1	f	23.7	185	280	365
6a	2.8	m	33.7	68	150	200	both animals: strong saliva production and tear fluid production. "a" vomits after 145 min, in narcosis spasm and heavy breathing; "b" coughing	in both animals excitement of reflexes possible within 1/4 to 1/2 hour. In the following days reduced appetite. Urine: in both animals increased protein concentration, both survive. In "a" diarrhoea
6b	2.6	m	33.7	106	175	204
7a	2.2	f	35	83	140	195	both animals: strong saliva production and tear fluid production	in both animals excitement of reflexes possible withing 1/2 hour. In the following days both droopy. Both survive.
7b	2.5	m	35	94	185	200
8a	4.2	m	48	35	122	170	both animals: strong saliva production and tear fluid production	in both animals: after 30-40 min sensation of corneal reflex possible, after 3 and 4 hours standing on their legs. In the following three days both droopy. In "a" strong conjunctivitis. Both surviving.
8b	3.5	m	48	45	90	140
9a	3.1	m	51	30	90	110	both animals: strong saliva production and tear fluid production	in both animals: after 20 min excitement of reflexes possible. In the following 2-4 days both droopy, reduced appetite. Both surviving.
9b	2.8	m	51	35	80	105
10a	2.6	m	56	28	55	75	both animals: strong saliva production and tear fluid production	in both animals: after 1/4 hour excitement of reflexes possible. After 1 hour again on their legs. In the following 2-3 days not at full conscience, reduced appetite. In "b" diarrhoea, surviving.
10b	3.1	m	56	30	60	85