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EC number: 204-662-3 | CAS number: 123-92-2
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Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Deficiencies in details about tested material and methodology. The study is not performed according to an acknowledged standard method.
Data source
Reference
- Reference Type:
- publication
- Title:
- Zur toxikologie der lösungsmittel
- Author:
- Ferdinand Flury und Wolfgang Wirth
- Year:
- 1 933
- Bibliographic source:
- International Archives of Occupational and Environmental Health Springer Berlin / Heidelberg ISSN 0340-0131 (Print), Heft Volume 5, Number 1, Seiten 1-90, Dezember 1933, DOI 10.1007/BF02274996
Materials and methods
- Principles of method if other than guideline:
- exposure of cats to "i-Amylacetat" at constant concentrations up to 56 mg/l via inhalation in a flow through apparatus, followed by investigations of effects: effects on behaviour and narcotic effects, effects on eyes and saliva production, food consumption, body temperature, protein content in urine, diarrhoea
- GLP compliance:
- no
Test animals
- Species:
- cat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: "streaming gas mixture"
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- other: LOAEL
- Effect level:
- 11 600 mg/m³ air
- Remarks on result:
- other: 2 animals (cat), in both animals increase of tear fluid production, in the beginning increase of saliva production.
Any other information on results incl. tables
Results:
The limit concentration that led to narcosis after 6 hours exposure time (inhalation) was 24 mg/l. In the following table the results are laid out.
Trial | Animal | Sex of animal | Conc. test substance in air | Effect on behaviour during exposure | Behaviour/effects after the trial | |||
Trial Nr. (a and b are animals at the same time) | body weight (kg) | (m or f) | (mg/l) | disturbance of equilibrium after ... min | remaining lied down after ... min | deep narcosis after ... min | other symptoms | |
1a | 2.2 | m | 11.6 | / | / | / | in both animals increase of tear fluid production, in the beginning increase of saliva production | in both animals no particular after effects |
1b | 2.5 | m | 11.6 | / | / | / | ||
2a | 3.2 | m | 12.6 | / | / | / | in both animals increase of tear fluid production, in the beginning strong increase of saliva production | both animals eat immediately after treatment, no particular after effects |
2b | 3.2 | m | 12.6 | / | / | / | ||
3a | 2.8 | m | 15.4 | 335 | / | / | in both animals increase of tear fluid production, in the beginning strong increase of saliva production | both animals eat immediately after treatment, no particular after effects |
3b | 3.3 | m | 15.4 | 335 | / | / | ||
4a | 2.2 | f | 15.4 | 368 | 423 | 493 | in both animals strong saliva production and tear fluid production. Animal "a" vomits after 420 min | "a" within 15 min excitement of reflexes possible, not at full conscience in the following days. Death after 6 days. Examination of body: lungs hyperaemic and found infested by parasites, death not deemed to be directly related to exposure to test substance. "b" recovers after one hour and survives without particular after effects. Rectal temperature, before treatment: "a" 38.4 °C, "b" 38.3 °C, after treatment: "a" 35.1 °C, "b" 37.2 °C |
4b | 2.2 | f | 15.4 | 368 | / | / | ||
5a | 2.1 | m | 23.7 | 105 | 225 | 305 | both animals: strong saliva production and tear fluid production. "a" shows clonic spasm after 235 min | in both animals excitement of reflexes possible within 1/2 hour. In the following 2 days both not at full conscience. "a" vomiting several times, surviving. Rectal temperature, before treatment: "a" 38.2 °C, "b" 37.9 °C, after treatment: "a" 35.0 °C, "b" 35.0 °C |
5b | 2.1 | f | 23.7 | 185 | 280 | 365 | ||
6a | 2.8 | m | 33.7 | 68 | 150 | 200 | both animals: strong saliva production and tear fluid production. "a" vomits after 145 min, in narcosis spasm and heavy breathing; "b" coughing | in both animals excitement of reflexes possible within 1/4 to 1/2 hour. In the following days reduced appetite. Urine: in both animals increased protein concentration, both survive. In "a" diarrhoea |
6b | 2.6 | m | 33.7 | 106 | 175 | 204 | ||
7a | 2.2 | f | 35 | 83 | 140 | 195 | both animals: strong saliva production and tear fluid production | in both animals excitement of reflexes possible withing 1/2 hour. In the following days both droopy. Both survive. |
7b | 2.5 | m | 35 | 94 | 185 | 200 | ||
8a | 4.2 | m | 48 | 35 | 122 | 170 | both animals: strong saliva production and tear fluid production | in both animals: after 30-40 min sensation of corneal reflex possible, after 3 and 4 hours standing on their legs. In the following three days both droopy. In "a" strong conjunctivitis. Both surviving. |
8b | 3.5 | m | 48 | 45 | 90 | 140 | ||
9a | 3.1 | m | 51 | 30 | 90 | 110 | both animals: strong saliva production and tear fluid production | in both animals: after 20 min excitement of reflexes possible. In the following 2-4 days both droopy, reduced appetite. Both surviving. |
9b | 2.8 | m | 51 | 35 | 80 | 105 | ||
10a | 2.6 | m | 56 | 28 | 55 | 75 | both animals: strong saliva production and tear fluid production | in both animals: after 1/4 hour excitement of reflexes possible. After 1 hour again on their legs. In the following 2-3 days not at full conscience, reduced appetite. In "b" diarrhoea, surviving. |
10b | 3.1 | m | 56 | 30 | 60 | 85 |
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