Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Deficiencies in details about tested material and methodology. Only few animals have taken part in study. The study is not performed according to an acknowledged standard method.

Data source

Materials and methods

Principles of method if other than guideline:
subcutaneous injection of test substance and subsequent examination of behaviour, physiological effects and organs
GLP compliance:

Test material

Constituent 1
Chemical structure
Reference substance name:
Isopentyl acetate
EC Number:
EC Name:
Isopentyl acetate
Cas Number:
Molecular formula:
Details on test material:
The degree of purity and composition of "isoamyl acetate (IAA)" (term as stated in the abstract) is unclear. No information is given on the content of other pentyl acetate isomers.

Test animals

other: cat and guinea pig
not specified

Administration / exposure

Route of administration:
not specified

Results and discussion

Any other information on results incl. tables


Animal species Applied dose subcutaneous per body weight of animal (g/kg) Effects
cat 3 Animal not fully conscious but recovering. Killed after 12 days. Body examination: nutmeg liver, other organs without any particularities
cat 3 Animal not fully conscious but recovering. Killed after 6 days. Body examination: no particularities found
guinea pig 1 survived
guinea pig 3 survived
guinea pig 5 After 1/2 hour deep narcosis, thereafter rear extremities paralysed. Death after 6 days. 

Conclusion: The lethal dose in a guinea pig was 5000 mg/kg body weight. Supposedly this result was obtained from testing a single animal.

Applicant's summary and conclusion