Registration Dossier

Administrative data

Endpoint:
genetic toxicity in vivo
Remarks:
Type of genotoxicity: other: Prediction of chromosome aberration
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Study period:
2011
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Toxtree (version 2.5.0.) modeling tool was developed by IDEA Consult Ltd (Sofia, Bulgaria) and is approved and recommended by the EU Joint Research Center in Ispra (Italy) (LINK: http://ecb.jrc.ec.europa.eu/qsar/qsar-tools/index.php?c=TOXTREE).
Justification for type of information:
QSAR prediction

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2011
Report Date:
2011

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Prediction by the Toxtree modelling tool
GLP compliance:
no
Type of assay:
micronucleus assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Bis(2,6-diisopropylphenyl)carbodiimide

Test animals

Species:
other: not applicable

Results and discussion

Test results
Genotoxicity:
other: No alerts for the micronucleus assay (Class II)

Any other information on results incl. tables

Explanation of rules:

QSA1.Acyl halidesNo
QSA2.Alkyl (C5) or benzyl ester of sulphonic or phosphonic acid
No
QSA3.N-methylol derivatives
No
QSA4.Monohaloalkene
No
QSA5.S or N mustard
No
QSA6.Propiolactones and propiosultones
No
QSA7.Epoxides and aziridines
No
QSA8.Aliphatic halogens
No
QSA9.Alkyl nitrite
No
QSA10.α,β unsaturated carbonyls
No
QSA11.Simple aldehyde
No
QSA12.Quinones
No
QSA13.Hydrazine
No
QSA14.Aliphatic azo and azoxy
No
QSA15.Isocyanate and isothiocyanate groups
No
QSA16.Alkyl carbamate and thiocarbamate
No
QSA18.Polycyclic Aromatic Hydrocarbons
No
QSA19.Heterocyclic Polycyclic Aromatic Hydrocarbons
No
QSA21.Alkyl and aryl N-nitroso groups
No
QSA22.Azide and triazene groups
No
QSA23.Aliphatic N-nitro
No
QSA24.α,β unsaturated alkoxy
No
QSA25.Aromatic nitroso group
No
QSA26.Aromatic ring N-oxide
No
QSA27.Nitro aromatic
No
QSA28.Primary aromatic amine, hydroxyl amine and its derived esters (with restrictions)
No
QSA28bis.Aromatic mono- and dialkylamine
No
QSA28ter.Aromatic N-acyl amine
No
QSA29.Aromatic diazo
No
QSA30.Coumarins and Furocoumarins
NoQSA32.1,3-dialkoxy-benzeneNo
QSA33.1-phenoxy-benzene
No
QSA34.H-acceptor-path3-H-acceptor
No
QSA35.Oxolane
No
QSA36.Carbodiimides
No
QAny alert?.At least one alert fired?
NoClassNo alerts for the micronucleus assay (Class II)

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative Modelling results
No structural alert was identified for the micronucleus assay.
Executive summary:

Genetic toxicity potential of bis(2,6 -diisopropylphenyl)carbodiimide was assessed using the Toxtree (version 2.5.0.) modelling tool . Toxtree was developed by IDEA Consult Ltd (Sofia, Bulgaria) and is approved and recommended by the EU Joint Research Center in Ispra (Italy) (LINK:http://ecb.jrc.ec.europa.eu/qsar/qsar-tools/index.php?c=TOXTREE). According to the modelling results of Toxtree, no structural alerts were identified for bis(2,6-diisopropylphenyl)carbodiimide, which might induce positive response in in-vivo micronucleus assay.