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Short-term toxicity to fish

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Description of key information

The LC50 of acute toxicity of n-butylchlorid to fish is reported at 75.6 mg/L. 

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
75.6 mg/L

Additional information

The key study for the toxicitxy of 1-chlorobutane to fish tested the effect of the substance toDanio rerioaccording to OECD 203 under GLP conditions (Study director 1990b). Six concentrations in the range of 26 to 140 mg/L (plus 3.6 mg/L Tween 80 per concentration as emulsifier) were tested under semi-static conditions, with a resulting LC50(96h) value of 75.6 mg/L (nominal).

Five further supporting studies report LC50 values in the range of 79.9 to 600 mg/L.

The first supporting study was conducted by the Ministry of the Environment of the Government of Japan (1995) according to OECD 203 under semi-static and closed conditions. The effects of five concentrations of the test substance in the range of 30.9 to 324 mg/L were tested to Oryzias latipes (550 mg/L DMSO was the final concentration of vehicle in each test concentration). An LC50(96h) value of 207 mg/L was calculated from the test results.

Another study was conducted under the Ministry of Economy, Trade and Industry (1991) under semi-static conditions, according to a national guideline and under GLP conditions. HCO-40 was applied as vehicle (unknown concentration) and the endpoint was calcualted at 79.9 mg/L as lethal concentration to Oryzias latipes after 48 hours.

The Ministry of the Environment, Government of Japan, finalised a report in 1993 on a study according to OECD 203 which applied a vehicle mixture (DMSO and HCO-40) of unknown concentration (>100 mg/L) with Oryzias latipes and derived an LC50(96h) value of 120 mg/L.

Another supporting value derives from a publication by Yen et al. in 2002. The study was conducted according to OECD 203 and tested toxicity to Cyprinus carpio under semi-static conditions. The reported LC50 value after >48 hours was 258.6 mg/L (water exchange at 48 hours, overall duration not reported).

A study of unassigned reliability by Hüls in 1978 reported an LC50(48h) value of 600 mg/L as effect concentration to Leuciscus idus.