Registration Dossier
Registration Dossier
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EC number: 271-138-9 | CAS number: 68516-20-1 A complex combination of hydrocarbons produced by the distillation of products from a steam-cracking process. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C7 through C12 and boiling in the range of approximately 130°C to 220°C(266°F to 428°F).
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Non-human information
A maximisation test in accordance with EU guideline B6 (Skin sensitisation) was performed by NOTOX (1996) to assess the sensitisation potential of toluene in guinea pigs. A grade 1 reaction (discrete or patchy erythema) was seen in 1/20 tested animals in response to challenge with a 50% solution. No other skin reactions were observed. It was concluded that toluene was not a skin sensitiser in this study.
Human information
There are no reports of skin sensitisation in humans attributed to toluene.
Migrated from Short description of key information:
The available animal data are sufficient to conclude that toluene is not a skin sensitiser. This is supported by the lack of human case reports for this high tonnage and widely used material.
Justification for selection of skin sensitisation endpoint:
Results from a guideline study provide no evidence of a potential to induce or elicit skin sensitisation
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No data animal or human data have been found with regard to respiratory sensitisation.
Migrated from Short description of key information:
No data have been found concerning respiratory sensitisation and there are no indications that toluene is a respiratory allergen.
Justification for selection of respiratory sensitisation endpoint:
No data have been found concerning respiratory sensitisation and there are no indications that toluene is a respiratory allergen
Justification for classification or non-classification
The animal data supported by the lack of human case studies reporting skin or respiratory sensitisation allow for the overall conclusion that, according to the GHS / CLP criteria, toluene does not require classification for sensitisation properties.
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