Cobalt carbonate

Developmental toxicity / teratogenicity

Administrative data

Endpoint:

developmental toxicity

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data from collection of data.

Data source

Reference

Reference 1

Reference Type:

review article or handbook

Title:

IARC Monographs on the evaluation of carcinogenic risks to humans. Cobalt and cobalt compounds.

Author:

International Agency for Research on Cancer

Year:

1991

Bibliographic source:

IARC 1991 52 363: 1017-1606

Reference 2

Reference Type:

publication

Title:

Does cobalt damage the hamster embryo? A preliminary report (Abstract).

Author:

Gale TF

Year:

1980

Bibliographic source:

Anat. Rec. 196: 232A

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Subcutaneous application of the test substance on GD8, determination of resorptions and effects on prenatal development of offspring on GD15.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Cobalt di(acetate)

EC Number:

200-755-8

EC Name:

Cobalt di(acetate)

Cas Number:

71-48-7

IUPAC Name:

cobalt(2+) diacetate

Details on test material:

- Name of test material (as cited in study report): cobalt acetate
- Analytical purity: not reported

Test animals

Species:

hamster

Strain:

not specified

Administration / exposure

Route of administration:

subcutaneous

Vehicle:

not specified

Analytical verification of doses or concentrations:

not specified

Duration of treatment / exposure:

acute exposure on GD 8

Frequency of treatment:

single

Duration of test:

GD 8 to 15

Doses / concentrations

Remarks:

Doses / Concentrations:
40, 60, 80, 100, 160 mg/kg bw
Basis:
nominal conc.

No. of animals per sex per dose:

not reported

Control animals:

not specified

Examinations

Ovaries and uterine content:

The ovaries and uterine content was examined after termination: Yes
Examinations included:
- Gravid uterus weight: No data
- Number of corpora lutea: No data
- Number of implantations: No data
- Number of resorptions: Yes (not further specified)

Fetal examinations:

- Central nervous system examinations: Yes

Results and discussion

Results: maternal animals

Maternal developmental toxicity

Details on maternal toxic effects:

Maternal toxic effects:no data

Results (fetuses)

Details on embryotoxic / teratogenic effects:

Embryotoxic / teratogenic effects:yes

Details on embryotoxic / teratogenic effects:
central nervous system defects

Effect levels (fetuses)

Dose descriptor:

LOAEL

Effect level:

40 mg/kg bw (total dose)

Basis for effect level:

other: fetotoxicity

Fetal abnormalities

Abnormalities:

not specified

Overall developmental toxicity

Developmental effects observed:

not specified

Any other information on results incl. tables

Foetal damage was detected on gestation day 15 in hamsters administered cobalt acetate (40, 60, 80, 100 or 160 mg/kg bw) subcutaneously on day 8 of pregnancy, The resorption rate ranged from 6% at the low dose to 100% at the high dose. Central nervous system defects were reported at the median doses. No information on maternal toxicity was reported.