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EC number: 223-496-2 | CAS number: 3923-79-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- basic information given; scientifically acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- In accordance with the techniques specified in the Regulations for the Enforcement of the Federal Hazardous Substances Act (Code of Federal Regulatioris, Title 16, Part 1500).
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- 4,5-dihydroxy-1,3-dimethylimidazolidin-2-one
- EC Number:
- 223-496-2
- EC Name:
- 4,5-dihydroxy-1,3-dimethylimidazolidin-2-one
- Cas Number:
- 3923-79-3
- Molecular formula:
- C5H10N2O3
- IUPAC Name:
- 4,5-dihydroxy-1,3-dimethylimidazolidin-2-one
- Details on test material:
- Name of the test substance used in the study report: Textile Resin NF-U
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The rabbits were individually identified by means of numbered ear tags.
The rabbits were housed in individual stainless steel cages suspended above the droppings. Food, consisting of Purina Laboratory Chow, and water were available at all times. The animals were kept on a 12-hour light/12-hour dark cycle.
Weight range 2431 to 3000 gram.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The rabbits were acclimated to the laboratory for at least 10 days before being dosed. The dose was applied to the abdominal skin area from which the fur had been previously removed with electric clippers. The abdominal skin area of half of the rabbits in the group was abraded by making a series of longitudinal minor epidermal incisions placed two to three centimeters apart, using a hypodermic needle as a cutting tool. The abrasions were sufficiently deep to penetrate the epidermis but not to induce bleeding. The skin of the remaining rabbits in the group remained intact. An equal number of males and females were assigned to the intact skin and abraded skin sub-groups.
The undiluted sample was applied at a dosage level of 3.0 ml/kg of body weight. The sample was introduced into a sleeve of rubber dental damming which was wrapped around the trunk of the animal and secured with staples. An outer layer of gauze and tape was placed around the trunk of the animal. The rabbit was restrained for 24 hours in a Newmann harness.
At the end of the 24-hour exposure period the binder was removed and any unabsorbed sample remaining on the skin was removed by gentle sponging with a moistened towel.
Each rabbit was examined throughly for gross signs of systemic toxicity and dermal irritation.
All rabbits were maintained for 14 days following completion of the exposure period. Examinations for gross signs of systemic toxicity and dermal irritation were carried out at frequent intervals during this period. At the end of the 14-day observation period the rabbits were weighed, sacrificed by T-61 overdose, and a gross necropsy was performed on each animal. - Duration of exposure:
- 24 hours
- Doses:
- 3.0 mL/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 300 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- none
- Clinical signs:
- other: Upon removal of the binders from the animals, the exposed area and binder appeared dry with no sample apparent on any of the animals. This proved evidence of complete dermal absorption of the sample. Irritative effects noted during the study included eryt
- Gross pathology:
- Gross necropsies performed at the termination of the study revealed pitted kidneys in one animal. No other gross-pathological alterations or lesions were noted in any of the rabbits.
Any other information on results incl. tables
Body weight changes (dose level: 3.0 ml/kg):
Rabbit No. | Sex | Skin | Body weight | |||
Intact | Abraded | Start (gm) | Finish (gm) | Change (gm) | ||
1 | male | x | 2691 | 2971 | 280 | |
2 | male | x | 2964 | 3292 | 328 | |
3 | male | x | 3000 | 3531 | 531 | |
4 | female | x | 2998 | 3327 | 329 | |
5 | male | x | 2940 | 3069 | 129 | |
6 | male | x | 2995 | 3215 | 220 | |
7 | female | x | 2999 | 3302 | 303 | |
8 | female | x | 2599 | 2709 | 110 | |
9 | female | x | 2431 | 3024 | 593 | |
10 | female | x | 2775 | 3145 | 370 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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