Registration Dossier
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EC number: 203-639-5 | CAS number: 109-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
A realistic worst-case BCF of 3.9 L/kg will be used in risk assessment for 1-methylpiperazine. This value is read-across from a BCF study from piparzine.
Key value for chemical safety assessment
- BCF (aquatic species):
- 3.9 L/kg ww
Additional information
Based on a low log pow value (log Pow= -0.57), no bioaccumulation of 1 -methylpiperazine is expected.
Based on the results a bioaccumulation study with piperazine in Cyprinus carpio (OECD 305C), cited in the EU Risk Assessment report for piperazine, support this conclusion. The bioaccumulation was investigated during 42 days at 25°C, at two test concentrations, 0.1 and 1.0 mg piperazine/L. BCF was determined to be 0.9 at the lower concentration, <3.9 at the higher concentration. Considering the limit difference in measured log Kow and the strong similarities between both structures it is considered justified to use the highest observed value for read across from the source chemical piperazine to the target chemical 1 -methylpiperazine. The higher BCF of 3.9 L/kg will as a worst-case be used in risk assessment for the evaluation of 1 -methyl piperazine.
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