Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-639-5 | CAS number: 109-01-3
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Significant accumulation in organisms is not to be expected.
Key value for chemical safety assessment
Additional information
QSAR-disclaimer:
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
Furthermore, according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of the substance (Q)SAR results were used for aquatic bioaccumulation. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, and for reasons of animal welfare, further experimental studies on aquatic bioaccumulation are not provided.
Assessment:
Experimental data on the bioaccumulation of 1-methylpiperazine are not available; therefore, the bioaccumulation potential of 1-methylpiperazine was assessed using read-across to an experimentally determined BCF for the structurally similar substance piperazine (CAS 110-85-0) as well as using estimated BCF values using the valid and well-established QSAR model Catalogic BCF base-line v4.11 (OASIS Catalogic v5.14.1.5) for the substance itself and piperazine.
The bioaccumulation study for piperazine (CAS 110-85-0) was published by NITE (1979). The GLP guideline study was conducted under flow-through conditions using the test species Cyprinus carpio. The BCF was determined for two test concentrations (0.01 and 0.1 mg/L). The maximum BCF in the experiment was determined to be <= 3.9 L/kg.
This experimental result is supported with the estimation model: QSAR BCF baseline v4.11 (OASIS CATALOGIC v5.14.1.5). 1-Methylpiperazin as well as piperazine are completely within the applicability domain of the model. The model can estimate the BCF for substances considering mitigation factors like molecular size, water solubility, and metabolism. The resulting BCF values for both substances were almost identical: BCF = 3.0 L/kg. The maximum BCF, which does not consider any mitigating factors, was 9.5 L/kg for 1-methylpiperazine and 9.3 L/kg for piperazine. For both substances, water solubility had the highest impact on the bioaccumulation potential, while metabolism and molecular size reduce the BCF only to a minor part (BASF SE, 2020).
Based on the available experimental and estimated data, it can be concluded that significant accumulation in organisms is not to be expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
