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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

With high probability acutely not harmful to fish.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Dose descriptor:
Effect concentration:
> 100 mg/L

Additional information

The toxicity of 1-methylpiperazine was investigated in a limit test according to OECD 203 (Labcorp 8493667, 2022). Exposure of rainbow trout (Oncorhynchus mykiss) to the test item gave LC50 values based on the nominal test concentration of greater than 100 mg/L. The No Observed Effect Concentration (NOEC) was 100 mg/L. Analysis of the freshly prepared test preparations at 0, 24, 48 and 72 hours showed the measured test concentration to range from 83% to 106% of nominal. Analysis of the expired test preparations at 24, 48, 72 and 96 hours showed the measured test concentration to range from 92% to 100% of nominal. Therefore, the results relate to the nominal values.

These findings are supported by a study according to DIN 38412, part 15 on the Golden orfe, Leuciscus idus (BASF AG, 1988.10F0175/885150). In this study, the 96-hour LC50 was determined to be > 1000 mg/L, i.e. the highest concentration tested based on nominal concentrations. No sublethal effects were observed. The no observed-effect concentration (NOEC) was 1000 mg/L (nominal), the highest concentration tested.

It can be concluded that the substance is with high probability acutely not harmful to fish.