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EC number: 203-639-5 | CAS number: 109-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06 - 13 November 1967
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: BASF-Test: Test was based on the Inhalation Hazard (Inhalation Risk) test and was performed in principle according to OECD Guideline 403.
The test is aimed to demonstrate the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temperature chosen for vapour generation (room temperature). 3 rats per sex were exposed sequentially to the vapours, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glassdisc in a glass cylinder for 1, 3 and 8 h. The documentation of clinical signs was performed over a period of 7 days. - GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- other: inhalation hazard test
- Limit test:
- no
Test material
- Reference substance name:
- 1-methylpiperazine
- EC Number:
- 203-639-5
- EC Name:
- 1-methylpiperazine
- Cas Number:
- 109-01-3
- Molecular formula:
- C5H12N2
- IUPAC Name:
- 1-methylpiperazine
- Details on test material:
- - Name of test material (as cited in study report): Monomethylpiperazin
- Analytical purity: 99 %
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Monomethylpiperazin
- Analytical purity: 99 %
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 171 g (mean)
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- no
- Remarks on duration:
- 1, 3 or 8 h
- Concentrations:
- 1 h exposure: 21.39 mg/l
3 h exposure: 21.39 mg/l
8 h exposure: 12.30 mg/l
Nominal concentrations. No verification of concentration by analysis. - No. of animals per sex per dose:
- 1 h exposure: 6
3 h exposure: 3
8 h exposure: 3 - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 21.39 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Remarks on result:
- other: No mortalities in 6 males and 6 females exposed to saturated vapour at room temperature
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 21.39 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 3 h
- Remarks on result:
- other: 50% mortality; exposed to saturated vapour at room temperature
- Sex:
- male/female
- Dose descriptor:
- LC100
- Effect level:
- 12.3 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: 100% mortality; exposed to saturated vapour at room temperature
- Mortality:
- 8 h exposure: 4 animals died within 7 h, 1 animal after 24 h and 1 animal after 6 days.
3 h exposure: 3 animals died within 24 h.
1 h exposure: no mortalities. - Clinical signs:
- other: see below
- Body weight:
- The surviving animals gained weight.
- Gross pathology:
- Animals that died: serous crusts at noses and eyes, hyperemia of the lungs.
- Other findings:
- 8 h exposure: Initially escape attempts, irritation of mucous membranes, dyspnoea. After the exposure staggering and tremor, swelling of the paws.
3 h exposure: Initially escape attempts, irritation of mucous membranes, dyspnoea. 5 h post exposure crusted
Any other information on results incl. tables
Mortality:
24 h | 7 days | ||||
1 h exposure | 0/12 | 0/12 | |||
3 h exposure | 3/6 | 3/6 | |||
8 h exposure | 4/6 | 6/6 |
Mean weight (g):
day 0 | day 7 | ||||
1 h exposure | 175 | 193 | |||
3 h exposure | 163 | 201 | |||
8 h exposure | 170 | - |
The inhalation of a highly enriched/saturated vapor-air-mixture caused mortality within 3 h.
There is indication that the test substance causes local irritation to exposed tissue including respiratory tract.
Applicant's summary and conclusion
- Conclusions:
- The inhalation of a highly enriched/saturated vapor-air-mixture caused mortality within 3 h. The test substance causes local irritation to exposed tissue including respiratory tract.
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