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Environmental fate & pathways

Biodegradation in water: screening tests

Administrative data

Endpoint:
biodegradation in water: ready biodegradability
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See attached QPRF and QMRF documents.

Data source

Referenceopen allclose all

Reference Type:
other: Estimation software
Title:
Estimation Programs Interface Suite for Microsoft Windows, v4.11
Author:
US EPA
Year:
2012
Bibliographic source:
United States Environmental Protection Agency, Washington DC, USA; November 2012
Reference Type:
publication
Title:
Group contribution method for predicting probability and rate of aerobic biodegradation.
Author:
Boethling, R.S., Howard, P.H., Meylan, W., Stiteler, W., Beaumann, J., Tirado, N.
Year:
1994
Bibliographic source:
Environ. Sci. Technol. 28:459-65.
Reference Type:
publication
Title:
Predicting Ready Biodegradability of Premanufacture Notice Chemicals.
Author:
Boethling, R.S., Lynch. D.G., Thom, G.C.
Year:
2003
Bibliographic source:
Environ. Toxicol. Chem. 22:837-844.
Reference Type:
publication
Title:
BIOWIN v4.10 (September 2010)
Author:
US EPA
Year:
2010
Bibliographic source:
United States Environmental Protection Agency, Washington, DC, USA.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: REACH guidance on information requirements and chemical safety assessment, chapter R.6: QSARs and grouping of chemicals.
Version / remarks:
May 2008
Principles of method if other than guideline:
(Q)SAR calculation: EPIWEB V4.1 - Biowin V 4.10
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Peptones, casein
EC Number:
293-428-4
EC Name:
Peptones, casein
Cas Number:
91079-40-2
Molecular formula:
Not applicable
IUPAC Name:
Peptones, casein
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
L-arginine (CAS# 74-79-3): NC(CCCNC(N)=N)C(O)=O
Glycine (CAS# 56-40-6): NCC(O)=O
Alanine (CAS# 302-72-7): C[C@H](N)C(O)=O
Phenlalaine (CAS# 63-91-2): N[C@@H](CC1=CC=CC=C1)C(O)=O
Trytophan (CAS# 73-22-3): N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

Results and discussion

% Degradationopen allclose all
Parameter:
probability of ready biodegradability (QSAR/QSPR)
Remarks:
yes
Remarks on result:
readily biodegradable based on QSAR/QSPR prediction
Remarks:
CAS# 73-22-3
Parameter:
probability of ready biodegradability (QSAR/QSPR)
Remarks:
yes
Remarks on result:
readily biodegradable based on QSAR/QSPR prediction
Remarks:
CAS# 56-40-6
Parameter:
probability of ready biodegradability (QSAR/QSPR)
Remarks:
yes
Remarks on result:
readily biodegradable based on QSAR/QSPR prediction
Remarks:
CAS# 302-72-7
Parameter:
probability of ready biodegradability (QSAR/QSPR)
Remarks:
yes
Remarks on result:
readily biodegradable based on QSAR/QSPR prediction
Remarks:
CAS# 63-91-2
Parameter:
probability of ready biodegradability (QSAR/QSPR)
Remarks:
yes
Remarks on result:
readily biodegradable based on QSAR/QSPR prediction
Remarks:
CAS# 74-79-3
Details on results:
See attached QSPR for individual BioWin results.

Applicant's summary and conclusion

Validity criteria fulfilled:
not applicable
Interpretation of results:
readily biodegradable
Conclusions:
Peptone, casein is registered as a UVCB as its composition can vary a lot depending on the manufacture process, although amino acids are the majority constituent(s). The biodegradation obtained from BIOWIN v4.10 QSAR model for several amino acids are concluded as biodegradable; therefore peptones, casin should be considered biodegradable.
Executive summary:

Peptone, casein is registered as a UVCB as its composition can vary a lot depending on the manufacture process, although amino acids are the majority constituent(s). The biodegradation obtained from BIOWIN v4.10 QSAR model for several amino acids are concluded as biodegradable; therefore peptones, casin should be considered biodegradable.