Registration Dossier
Registration Dossier
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EC number: 233-060-3 | CAS number: 10026-13-8
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Administrative data
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Additional information
Phosphorus pentachloride decomposes on contact with water/moisture to form phosphoric acid and hydrochloric acid. The evaluation of short-term toxicity to aquatic invertebrates is conducted with the approach of weight of evidence considering one study about hydrochloric acid (EC50 48h is pH= 5.3, equivalent to 0.492 mg/l of HCl) and one study about phosphoric acid (EC50 48h> 376 mg/l). To extrapolate the value for EC50 48h related to PCl5 precautionary principle the lower value of EC50 48h considering values of HCl and H3PO4 is chosen: the value related to hydrochloric acid is so preferred to phosphoric acid. EC50 48h for Daphnia magna was found to be pH 5.3,equivalent to 0.492 mg/l of HCl.
Considering the stoichiometry of hydrolysis reaction of PCl5 (PCl5 +4H2O-> H3PO4 +5HCl) this concentration of HCl is calculated to be equivalent to 0.56 mg/l of PCl5.
In the same manner (using approach of weight of evidence) the evaluation of short-term toxicity to aquatic algae and cyanobacteria is conducted considering one study about hydrochloric acid (EC50 72h growth rate is pH= 5.3, equivalent to 0.492 mg/l of HCl and NOEC 72h growth rate and biomass is pH= 6, equivalent to 0.097 mg/l of HCl) and one study about phosphoric acid (EC50 72h growth rate= 77.9 mg/l). To extrapolate EC50 72h and NOEC 72h related to PCl5 precautionary principle the lower value of EC50 72h growth rate considering values of HCl and H3PO4 is chosen: the value related to hydrochloric acid is so preferred to phosphoric acid. The growth rate is preferred to biomass because it is less precautionary but more realistic. EC50 72 h growth rate for Selenastrum capricornutum was reported to pH= 5.3 equivalent to 0.492 mg/l of HCl and NOEC 72 h growth rate and biomass was reported to be pH= 6 equivalent to 0.097 mg/l of HCl (See SIDS Hydrogen Chloride 2002). Considering the stoichiometry of hydrolysis reaction of PCl5 (PCl5 +4H2O-> H3PO4 +5HCl) these values of HCl are equivalent to EC50 72h (growth rate) = 0.56 mg/l and NOEC 72 h (growth rate and biomass)=0.11 mg/l for PCl5.
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