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Diss Factsheets

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Cytotoxicity of Amino Alcohols to Rat Hepatoma-derived Fa32 Cells
Author:
Scheers EM, Forsby A, Dierickx PJ
Year:
2002
Bibliographic source:
ATLA 30: 309-312 ( Nineteenth Scandinavian Cell Toxicology Congress)

Materials and methods

Type of study / information:
Cytotoxicity of rat hepatoma-derived Fa32 cells
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Cytotoxicity was measured by using a NRU (neutral red uptake) inhibition assay and was quantified by determination of the NI50, i.e. the concentration of test compound needed to induce a 50% reduction in NRU.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
3-aminopropan-1-ol
EC Number:
205-864-4
EC Name:
3-aminopropan-1-ol
Cas Number:
156-87-6
Molecular formula:
C3H9NO
IUPAC Name:
3-aminopropan-1-ol
Test material form:
liquid

Results and discussion

Any other information on results incl. tables

The NI50of 3-aminopropan-1 -ol was 13.4 ± 2.3 mM.

Applicant's summary and conclusion