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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Inhalation hazard test, animals exposed for 1 hour
GLP compliance:
not specified
Test type:
traditional method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-aminopropan-1-ol
EC Number:
205-864-4
EC Name:
3-aminopropan-1-ol
Cas Number:
156-87-6
Molecular formula:
C3H9NO
IUPAC Name:
3-aminopropan-1-ol
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Substance-ID: 78/701

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: MUS RATTUS, Brunnthal
- Weight at study initiation: 185 +/- 15 g
- Diet: Herilan MRH, ad libitum
- Water: Tap water, ad libitum

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
nose/head only
Vehicle:
air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: head-nose inhalation system
- Method of holding animals in test chamber: animals are held in a tube, the head/nose being exposed to the inhalation chamber

TEST ATMOSPHERE
- Brief description of analytical method used: gas chromatography
- Samples taken from breathing zone: yes
Analytical verification of test atmosphere concentrations:
yes
Remarks:
gas chromatography
Duration of exposure:
1 h
Concentrations:
0, 6.64, and 16.35 mg/L analytical concentration
No. of animals per sex per dose:
10 male and 10 female animals per dose
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of weighing: day 0, 7 and 14
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Statistics:
Data were anlysed according to the "Binominaltest" (Wittig H, Mathematische Statisik, 1974, pp 32-35)

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 16.4 mg/L air (analytical)
Based on:
test mat.
Exp. duration:
1 h
Mortality:
no death occurred
Clinical signs:
other: aqueous, reddish eye and nose secretion, irregular respiration, scrubby and clotted fur, hairless necrotic areas with bloody eschar. The animals were not free of symptoms at the end of the observation period (14 days).
Body weight:
male and female animals of the 16.35 mg/L dose group showed no differences compared to the control group. Male animals of the 6.64 mg/L dose group showed no differences compared to the control group. The female animals of the 6.64 mg/L dose group showed a slight weight loss after 7 days and decreased body weight gain after 14 days compared to controls.
Gross pathology:
nothing abnormal detected

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met