Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Data are available on the metabolism of acetate esters (including hexyl acetate) and indicate rapid enzymic hydrolysis in vivo

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
50
Absorption rate - dermal (%):
50
Absorption rate - inhalation (%):
100

Additional information

An IPCS Review indicates that hexyl acetate would be subject to rapid enzymic hydrolyis in vivo. The results of an in vitro study indicate that inhaled acetate esters including hexyl acetate are likely to be extensively hydrolysed by respiratory tract enzymes, resulting in little systemic exposure to the intact ester.