Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 906-256-8 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable, well-documented publication which meets basic scientific principles
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Assessment of the Developmental Toxicity of Ethylene Glycol Applied Cutaneously to CD-1 Mice.
- Author:
- Tyl, R.W., Fisher, L.C., Kubena, M.F., Vrbanic, M.A., Losco, P.E.
- Year:
- 1 995
- Bibliographic source:
- Fundamental and Applied Toxicology 27, 155 - 166
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
- Principles of method if other than guideline:
- LD50 derived from developmental toxicity study
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- testing lab.
- Test type:
- other: part of a developmental toxicity study.
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Type:
- Constituent
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- see developmental toxicity/teratogenicity
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- see developmental toxicity/teratogenicity
- Duration of exposure:
- see developmental toxicity/teratogenicity
- Doses:
- approx. 404 mg/kg, approx. 1677 mg/kg, approx. 3549 mg/kg
- No. of animals per sex per dose:
- see developmental toxicity/teratogenicity
- Control animals:
- yes
- Statistics:
- see developmental toxicity/teratogenicity
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- see developmental toxicity/teratogenicity
- Clinical signs:
- see developmental toxicity/teratogenicity
- Body weight:
- see developmental toxicity/teratogenicity
- Gross pathology:
- see developmental toxicity/teratogenicity
- Other findings:
- see developmental toxicity/teratogenicity
Any other information on results incl. tables
see developmental toxicity/teratogenicity
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- see developmental toxicity/teratogenicity
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
