Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25 to 26 March 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Recent study conducted by a GLP certified laboratory in accordance with a suitable study guideline.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
tris(propan-2-yl)silyl 2-methylprop-2-enoate
EC Number:
700-182-8
Cas Number:
134652-60-1
Molecular formula:
C13 H26 O2 Si
IUPAC Name:
tris(propan-2-yl)silyl 2-methylprop-2-enoate
Details on test material:
- Name of test material (as cited in study report): TIS-M
- Lot/batch No.: 9925
- Expiration date of the lot/batch: 2 December 2010
- Storage condition of test material: Under nitrogen at room temperature, continuously protected form all light.

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
> 6.5
Remarks on result:
other: Estimated
Details on results:
The retention time of TIS-M is higher than that of the last eluting standard, therefore an accurate value for the partition coefficient could not be given. The estimated partition coefficient value (log Pow) of TIS-M is higher than 6.5 and the extrapolated value is 7.4.

Applicant's summary and conclusion

Conclusions:
The estimated partition coefficient value for TIS-M is higher than 6.5 and the extrapolated partitition coefficient value is 7.4.
Executive summary:

The partition coefficient of the substance was assessed according to EC (A8) and OECD Guideline 117 using a HPLC method. was calibrated using the following reference substances: Thiorea, Ethyl Benzoate, Benzophenone, Diphenylamine, Naphthalene, Phenanthrene, Triphenylamine and DDT. The estimated partition coefficient value for TIS-M is higher than 6.5 and the extrapolated partitition coefficient value is 7.4.