Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
1 000 mg/kg bw
Quality of whole database:
No reliable acute oral toxicity data is available. However, from the results of a 14-day range-finding study for a reproduction/developmental toxicity study LD50 is > 1000 mg/kg bw/day can be concluded.

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
4 000 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
4 000 mg/kg bw

Additional information

 Several studies explored the acute toxicity of dibromomethane via the 3 main exposure routes (oral, dermal, and inhalation).

In a 4-hour inhalation study in rats receiving about 20 mg/L to 21-22 mg/L dibromomethane in air, no mortalities occurred and no lasting pathological changes were seen at 18 and 20 days post treatment. LC50> 22.3 mg/L was observed. 

Oral LD50was > 1000 mg/kg/bw was derived from a 14 day day range-finding study for a reproduction/developmental toxicity study conducted according to OECD TG 421 and US EPA OPPTS 870.3550.

No reliable acute dermal toxicity information is available. The results from a secondary source suggest dibromomethane is of low toxicity via the dermal route (LD50 > 4000 mg/kg bw/day).


Justification for selection of acute toxicity – oral endpoint
Most reliable source

Justification for selection of acute toxicity – inhalation endpoint
Most reliable source

Justification for selection of acute toxicity – dermal endpoint
Only available information

Justification for classification or non-classification