Registration Dossier
Registration Dossier
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EC number: 233-141-3 | CAS number: 10043-67-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed report
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- TOXICOLOGICAL PROFILE FOR ALUMINUM
- Author:
- Agency for Toxic Substances and Disease Registry (ATSDR)
- Year:
- 2 008
- Bibliographic source:
- Agency for Toxic Substances and Disease Registry Division of Toxicology and Environmental Medicine/Applied Toxicology Branch 1600 Clifton Road NE Mailstop F-32 Atlanta, Georgia 30333
- Reference Type:
- publication
- Title:
- Production of epidermal damage in mammalian skins by some simple aluminum compounds
- Author:
- Lansdown AB
- Year:
- 1 973
- Bibliographic source:
- Br J Dermatol 89:67-76
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Aluminium sulfate
- IUPAC Name:
- Aluminium sulfate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Carworth TF1
- Sex:
- female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 5d/ 1x/d
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- 10 other: % (w/v)
- Based on:
- dissolved
- Remarks:
- Aluminium as Aluminium sulfate
- Remarks on result:
- other: LD0 = 10% (w/v) Aluminium as Aluminium sulfate
- Mortality:
- no mortality
- Clinical signs:
- other: no skin damage
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- NOAEL-5d/1x/d mouse TFI: 10% (w/v) = 100 g/L as Aluminium sulfateCalculated for KAl(SO4)2: NOAEL: 13.25 % (w/v) = 132.5 g/L as KAl(SO4)2.The estimated LD50 should be > 2000 mg/kg bw for Aluminium potassium bis sulphate.Therefore aluminium potassium bis sulphate is not classified according to EU Regulation 1272/2008and 286/2011 (2. ATP).
- Executive summary:
NOAEL-5d/1x/d mouse TFI: 10% (w/v) = 100 g/L as Aluminium sulfate
Calculated for KAl(SO4)2:
NOAEL: 13.25 % (w/v) = 132.5 g/L as KAl(SO4)2.
The estimated LD50 should be > 2000 mg/kg bw for Aluminium potassium bis sulphate.
Therefore aluminium potassium bis sulphate is not classified according to EU Regulation 1272/2008
and 286/2011 (2. ATP).
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