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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: peer-reviewed report

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
TOXICOLOGICAL PROFILE FOR ALUMINUM
Author:
Agency for Toxic Substances and Disease Registry (ATSDR)
Year:
2008
Bibliographic source:
Agency for Toxic Substances and Disease Registry Division of Toxicology and Environmental Medicine/Applied Toxicology Branch 1600 Clifton Road NE Mailstop F-32 Atlanta, Georgia 30333
Reference Type:
publication
Title:
Production of epidermal damage in mammalian skins by some simple aluminum compounds
Author:
Lansdown AB
Year:
1973
Bibliographic source:
Br J Dermatol 89:67-76

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
EPA OPP 81-2 (Acute Dermal Toxicity)
Deviations:
not specified
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Reference substance name:
Aluminium sulfate
IUPAC Name:
Aluminium sulfate

Test animals

Species:
mouse
Strain:
other: Carworth TF1
Sex:
female

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
5d/ 1x/d
Control animals:
not specified

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD0
Effect level:
10 other: % (w/v)
Based on:
dissolved
Remarks:
Aluminium as Aluminium sulfate
Remarks on result:
other: LD0 = 10% (w/v) Aluminium as Aluminium sulfate
Mortality:
no mortality
Clinical signs:
other: no skin damage

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
NOAEL-5d/1x/d mouse TFI: 10% (w/v) = 100 g/L as Aluminium sulfateCalculated for KAl(SO4)2: NOAEL: 13.25 % (w/v) = 132.5 g/L as KAl(SO4)2.The estimated LD50 should be > 2000 mg/kg bw for Aluminium potassium bis sulphate.Therefore aluminium potassium bis sulphate is not classified according to EU Regulation 1272/2008and 286/2011 (2. ATP).
Executive summary:

NOAEL-5d/1x/d mouse TFI: 10% (w/v) = 100 g/L as Aluminium sulfate

Calculated for KAl(SO4)2:

NOAEL: 13.25 % (w/v) = 132.5 g/L as KAl(SO4)2.

The estimated LD50 should be > 2000 mg/kg bw for Aluminium potassium bis sulphate.

Therefore aluminium potassium bis sulphate is not classified according to EU Regulation 1272/2008

and 286/2011 (2. ATP).