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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: no OECD guideline, but well documented

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Production of epidermal damage in mammalian skins by some simple aluminum compounds
Author:
Lansdown, AB
Year:
1973
Bibliographic source:
Br. J. Dermatol. 89, 67-76
Reference Type:
secondary source
Title:
Toxicological Profile for Aluminum
Author:
ATSDR
Year:
2008
Bibliographic source:
ATSDR (2008) Toxicological Profile for Aluminium. U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, p. 91/92

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
EPA OPP 81-5 (Acute Dermal Irritation)
Deviations:
not specified
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Aluminium sulfate
IUPAC Name:
Aluminium sulfate

Test animals

Species:
mouse
Strain:
other: Carworth TF1
Details on test animals or test system and environmental conditions:
female TF1 Carworth mice

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Duration of treatment / exposure:
5d/1x/d

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
other: hyperplasia, micro abscess formation, dermal inflammatory cell infiltration, and occasional ulceration
Remarks on result:
other: no skin damage effects

Any other information on results incl. tables

NOAEL-5d/1x/d: 10%, no skin damage effects

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
NOAEL-5d/1x/d: 10 % (w/v), not irritating, no skin damage.Calculated for AlK(SO4)2: 13.25 % (w/v)Therefore the substance is not classified as skin irritating according EU-Regulation No. 1272/2008 (CLP)and EU regulation 286/2011 (2. ATP).
Executive summary:

NOAEL-5d/1x/d: 10%, not irritating, no skin damage.

Calculated for AlK(SO4)2: 13.25 % (w/v)

Therefore the substance is not classified as skin irritating according EU-Regulation 1272/2008 (CLP)

and EU regulation 286/2011 (2. ATP).