Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-141-3 | CAS number: 10043-67-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no OECD guideline, but well documented
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Production of epidermal damage in mammalian skins by some simple aluminum compounds
- Author:
- Lansdown, AB
- Year:
- 1 973
- Bibliographic source:
- Br. J. Dermatol. 89, 67-76
- Reference Type:
- secondary source
- Title:
- Toxicological Profile for Aluminum
- Author:
- ATSDR
- Year:
- 2 008
- Bibliographic source:
- ATSDR (2008) Toxicological Profile for Aluminium. U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, p. 91/92
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Aluminium sulfate
- IUPAC Name:
- Aluminium sulfate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Carworth TF1
- Details on test animals or test system and environmental conditions:
- female TF1 Carworth mice
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Duration of treatment / exposure:
- 5d/1x/d
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- other: hyperplasia, micro abscess formation, dermal inflammatory cell infiltration, and occasional ulceration
- Remarks on result:
- other: no skin damage effects
Any other information on results incl. tables
NOAEL-5d/1x/d: 10%, no skin damage effects
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- NOAEL-5d/1x/d: 10 % (w/v), not irritating, no skin damage.Calculated for AlK(SO4)2: 13.25 % (w/v)Therefore the substance is not classified as skin irritating according EU-Regulation No. 1272/2008 (CLP)and EU regulation 286/2011 (2. ATP).
- Executive summary:
NOAEL-5d/1x/d: 10%, not irritating, no skin damage.
Calculated for AlK(SO4)2: 13.25 % (w/v)
Therefore the substance is not classified as skin irritating according EU-Regulation 1272/2008 (CLP)
and EU regulation 286/2011 (2. ATP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
