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Description of key information

Key value for chemical safety assessment

Effect on immunotoxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Additional information

Justification for selection of effect on immunotoxicity via oral route endpoint:
Under experimental conditions of oral administration of dapsone in C57BL/6 mice, Dapsone did not result in a significant degree of immunotoxicity in C57BL/6 mice with the exception of the highest dose. The pattern of immunotoxicity that was observed appeared to be related to a marginal sensitivity in humoral immunity and manifested as augmented responses. In this regard, the possibility of a "rebound" effect cannot be ruled out.

Justification for classification or non-classification