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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Not specified
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
2005

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method not reported.

Reference: Gohlke VR, Lewa W, Strachovsky A, et al. 1969. [Animal experimental studies on the inhalatory effects of tributyltin chloride in a subchronic test.] Gezamte Hyg 15:97-104. (German)
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tributyltin chloride
EC Number:
215-958-7
EC Name:
Tributyltin chloride
Cas Number:
1461-22-9
Molecular formula:
C12H27ClSn
IUPAC Name:
tributylstannanylium chloride

Test animals

Species:
rat
Strain:
not specified
Sex:
female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remarks on MMAD:
MMAD / GSD: No data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
The animals were exposed to concentrations of 4–6 mg/m^3 (0.30–0.45 ppm) for 6 hours/day, 5 days/week for 95 days
Frequency of treatment:
6 hours/day, 5 days/week.
Doses / concentrationsopen allclose all
Dose / conc.:
4 mg/m³ air
Remarks:
4-6 mg/m^3
Dose / conc.:
6 mg/m³ air
Remarks:
4-6 mg/m^3
No. of animals per sex per dose:
No data
Control animals:
not specified

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Description (incidence and severity):
Inflamed eyes and nasal mucous membranes were observed in the last month of a 95-day inhalation study of the test material in female rats.
Gross pathological findings:
effects observed, treatment-related
Description (incidence and severity):
Inflammatory changes consisting of hyperaemia and bronchitis were observed in the respiratory system.
Fatty degeneration was observed at necropsy in animals killed after a 95-day exposure period.

Effect levels

Dose descriptor:
LOAEC
Effect level:
3 ppm
Based on:
test mat.
Sex:
female
Basis for effect level:
other: Respiratory, hepatic & ocular effects

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The LOAEL in female rats exposed to the test material was determined to be 3 ppm.
Executive summary:

The LOAEL in female rats exposed to the test material was determined to be 3 ppm.

Effects noted were inflammatory changes consisting of hyperaemia and bronchitis which were observed in the respiratory system.

Fatty degeneration was observed at necropsy in animals killed after a 95-day exposure period. Inflamed eyes and nasal mucous membranes were observed in the last month of a 95-day inhalation study of tributyltin chloride in female rats.