4-tert-butylpyrocatechol

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

report date: 2010-01-06

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

GLP compliance:

no

Type of method:

thermal analysis

Key result

Melting / freezing pt.:

54.95 °C

Atmospheric pressure during the assay has not been measured; the melting temperature was given without any correction.

Result of the melting point:

	Test item			Reference item
	Assay 1	Assay 2	Mean(+/- Standard deviation)	Measure	range
Weight (mg)	5.39	5.45	-	5.09	-
Melting point (°C)	55.0	54.9	54.95 +/- 0.05	121.6	121.3 – 122.7

According to the results of the reference item, the test has to be considered as valid.

Conclusions:

The melting point of 4-TBC is 54.95°C +/- 0.05°C.

Executive summary:

In a study (Processium, 2010), the melting point of 4-tert-butylpyrocatechol (4 -TBC) was assessed using the differential scanning calorimetry, according to the regulation (EC) n°440/2008, A.1, and to the OECD Guideline n°102.

 

A test item amount of 5 mg was heated up from 30 to 300°C with a rate of 10°C/min. During the experiment, two samples were measured. The quantities of heat absorbed or released were measured by Differential Scanning Calorimetry and recorded. A reference sample (around 5 mg) of benzoic acid was measured in order to evaluate the experimental procedure.

The results of the melting point of 4 -TBC were: 55°C and 54.9°C and of the reference item: 121.6°C.

According to the results of the reference item, the test has to be considered as valid.

In conclusion, the melting point of 4 -tert-butylpyrocatechol is 54.95°C +/- 0.05°C.

This study is classified as acceptable and satisfies the guideline requirements for a melting point study.

Description of key information

Melting point: 54.95°C +/- 0.05°C

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

54.95 °C

Additional information

One experimental study (Processium, 2010) with reliability 1 according to Klimisch was available and was selected as key study. Melting point was determined according to the regulation (EC) n°440/2008, A.1.

Data coming from peer-review handbooks were also available. As the values are in the same range, they are used in a supporting approach.