Registration Dossier
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EC number: 202-653-9 | CAS number: 98-29-3
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- report date: 2010-01-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- thermal analysis
- Key result
- Melting / freezing pt.:
- 54.95 °C
- Conclusions:
- The melting point of 4-TBC is 54.95°C +/- 0.05°C.
- Executive summary:
In a study (Processium, 2010), the melting point of 4-tert-butylpyrocatechol (4 -TBC) was assessed using the differential scanning calorimetry, according to the regulation (EC) n°440/2008, A.1, and to the OECD Guideline n°102.
A test item amount of 5 mg was heated up from 30 to 300°C with a rate of 10°C/min. During the experiment, two samples were measured. The quantities of heat absorbed or released were measured by Differential Scanning Calorimetry and recorded. A reference sample (around 5 mg) of benzoic acid was measured in order to evaluate the experimental procedure.
The results of the melting point of 4 -TBC were: 55°C and 54.9°C and of the reference item: 121.6°C.
According to the results of the reference item, the test has to be considered as valid.
In conclusion, the melting point of 4 -tert-butylpyrocatechol is 54.95°C +/- 0.05°C.
This study is classified as acceptable and satisfies the guideline requirements for a melting point study.
Reference
Atmospheric pressure during the assay has not been measured; the melting temperature was given without any correction.
Result of the melting point:
|
Test item |
Reference item |
|||
|
Assay 1 |
Assay 2 |
Mean(+/- Standard deviation) |
Measure |
range |
Weight (mg) |
5.39 |
5.45 |
- |
5.09 |
- |
Melting point (°C) |
55.0 |
54.9 |
54.95 +/- 0.05 |
121.6 |
121.3 – 122.7 |
According to the results of the reference item, the test has to be considered as valid.
Description of key information
Melting point: 54.95°C +/- 0.05°C
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 54.95 °C
Additional information
One experimental study (Processium, 2010) with reliability 1 according to Klimisch was available and was selected as key study. Melting point was determined according to the regulation (EC) n°440/2008, A.1.
Data coming from peer-review handbooks were also available. As the values are in the same range, they are used in a supporting approach.
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