Registration Dossier
Registration Dossier
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EC number: 201-375-5 | CAS number: 81-77-6
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Remarks:
- other: no data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological Evaluation of some Food Colours, Enzymes, Flavour Enhancers, Thickening Agents and Certain Food Additives
- Author:
- WHO
- Year:
- 1 974
- Bibliographic source:
- WHO Food Additives Series, 1974, No.6.
Materials and methods
- Principles of method if other than guideline:
- Twelve rats received subcutaneous injections of 2 ml of a 2.5 % aqueous suspension of the test substance.
- GLP compliance:
- no
Test material
- Reference substance name:
- 6,15-dihydroanthrazine-5,9,14,18-tetrone
- EC Number:
- 201-375-5
- EC Name:
- 6,15-dihydroanthrazine-5,9,14,18-tetrone
- Cas Number:
- 81-77-6
- Molecular formula:
- C28H14N2O4
- IUPAC Name:
- 6,15-dihydroanthrazine-5,9,14,18-tetrone
- Details on test material:
- - Name of test material (as cited in study report): Indanthrene Blue RS
No further data.
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Indanthrenene blue RS
No further data.
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- not specified
- Remarks:
- 2.5 % in an aqueous solution
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- monthly
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2.5%
- No. of animals per sex per dose:
- 12
- Control animals:
- not specified
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Six rats survived for 417 - 570 days. No tumours were seen at the site of injection.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
