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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April 22, 1988 to August 12, 1988
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Guideline study performed in compliance with GLP, available as unpublished report, no restrictions, fully adequate for assessment.
according to guideline
OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)
according to guideline
other: Directive 84/449/EEC, Annex V, A.7
GLP compliance:
Specific details on test material used for the study:
- Name of test material (as cited in study report): Tetrabenzylthiuram disulfide
- Physical state: Solid
- Storage condition of test material: At room temperature in the dark
- Analytical purity: 98 %
- Lot/batch No.: RB82 + RB87 + RB88 + RB92 + RB69
Key result
standard fat
ca. 190 g/kg solvent
37 °C
Test substance stable:
Details on results:
- Information on chemical stability: No significant difference were observed between the HPLC chromatograms of the standards and the samples.
- Other: After a shaking period of 24 hours there were no significant differences between the over- and undersaturated solution. Therefore, the fat solubility of the substance was calculated as a mean value from the results of the 24 hours measurements.

Description of key information

The solubility of the substance in standard fat was determined to be 1.9 g/kg at a temperature of 37 °C.

Key value for chemical safety assessment

Solubility in mg/100g standard fat:
At the temperature of:
20 °C

Additional information