Registration Dossier
Registration Dossier
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EC number: 404-310-0 | CAS number: 10591-85-2 PERKACIT TBZTD; PERKACIT TBZTD PDR; PERKACIT TBZTD PDR-D; TBZD
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Guideline study performed in compliance with GLP, available as unpublished report, no restrictions, fully adequate for assessment.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Tetrabenzylthiuram disulfide
- Substance type: Monoconstituent substance
- Physical state: Solid
- Storage condition of test material: At room temperature in the dark
- Lot/batch No.: RB82 + RB87 + RB88 + RB92 + RB69 - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. 3.7
- Temp.:
- 20 °C
- Remarks on result:
- other: Second log Pow = 3.4 relates probably to a decomposition product
- Conclusions:
- The determination of log Pow by High Performance Liquid Chromatography (HPLC) results in two log Pow
- Executive summary:
The log Pow of the substance was interpolated from this regression line which was obtained from nine reference substances. Two partition coefficients (noctanol/water) were associated with the test substance and determined to be 2.5 * 10E3 (log Pow = 3.4) and 5.0 * 10E3 (log Pow = 3.7) at 20.0 ± 0.50 C. The lower value represents probably a decomposition product, the higher the test substance.
Reference
Description of key information
The test substance is not stable in water. With a High Performance Liquid Chromatographic method two partition coefficients (n-octanol/water) were determined to be 2.5* 10E3 (log P = 3.4) and 5.0 * 10E3 (log P =3.7) at 20.0 ± 0.50 C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.7
- at the temperature of:
- 20 °C
Additional information
The pattern of a chromatogram of the test substance showed two different peaks, probably one derived from the test substance and one from decomposition product(s). The higher of the two log P values was associated with the original substance.
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