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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Guideline study performed in compliance with GLP, available as unpublished report, no restrictions, fully adequate for assessment.
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
- Name of test material (as cited in study report): Tetrabenzylthiuram disulfide
- Substance type: Monoconstituent substance
- Physical state: Solid
- Storage condition of test material: At room temperature in the dark
- Lot/batch No.: RB82 + RB87 + RB88 + RB92 + RB69
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
ca. 3.7
Temp.:
20 °C
Remarks on result:
other: Second log Pow = 3.4 relates probably to a decomposition product
Conclusions:
The determination of log Pow by High Performance Liquid Chromatography (HPLC) results in two log Pow
Executive summary:

The log Pow of the substance was interpolated from this regression line which was obtained from nine reference substances. Two partition coefficients (noctanol/water) were associated with the test substance and determined to be 2.5 * 10E3 (log Pow = 3.4) and 5.0 * 10E3 (log Pow = 3.7) at 20.0 ± 0.50 C. The lower value represents probably a decomposition product, the higher the test substance.

Description of key information

The test substance is not stable in water. With a High Performance Liquid Chromatographic method two partition coefficients (n-octanol/water) were determined to be 2.5* 10E3 (log P = 3.4) and 5.0 * 10E3 (log P =3.7) at 20.0 ± 0.50 C.

Key value for chemical safety assessment

Log Kow (Log Pow):
3.7
at the temperature of:
20 °C

Additional information

The pattern of a chromatogram of the test substance showed two different peaks, probably one derived from the test substance and one from decomposition product(s). The higher of the two log P values was associated with the original substance.

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