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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May 10, 1988 to July 7, 1988
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Guideline study performed in compliance with GLP, available as unpublished report, no restrictions, fully adequate for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Version / remarks:
(1981)
Deviations:
no
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrakis(phenylmethyl)thioperoxydi(carbothioamide)
EC Number:
404-310-0
EC Name:
Tetrakis(phenylmethyl)thioperoxydi(carbothioamide)
Cas Number:
10591-85-2
Molecular formula:
C30H28N2S4
IUPAC Name:
N,N-dibenzyl[(dibenzylcarbamothioyl)disulfanyl]carbothioamide
Specific details on test material used for the study:
- Substance: TETRABENZYLTHIURAM DISULFIDE
- Appearance: Powder (creamy, solid)
- Stability: At room temperature, protected from light.
- Protective measures: Gloves, goggl es and face mask were suffi cient to assure personnel health and safety.

Physical form of substance: Solid
Mass median aerodynamic diameter (for liq.+solid aerosol): MMAD has not been calculated. 47.7% of particles =< 3 um.
Cumulative particel size: Percent Effective cutoff diameter 4.0 < 0.325 4.2 0.325 4.7 0.715 6.3 1.06 11.0 1.60 26.8 2.13 47.7 3.0 100 4.6
- Batch: RB 67+65+77
- Purity: Technical pure product

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
Wistar rat, KFM-HAN, outbred, SPF quality

Administration / exposure

Route of administration:
inhalation: dust
Vehicle:
air
Details on inhalation exposure:
Nose-only
Duration of exposure:
4 h
Statistics:
The LOGIT-Model could not be applied to these data.

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 5.03 mg/L air
Exp. duration:
4 h
Mortality:
Male: .78 mg/L; Number of animals: 5; Number of deaths: 0
Male: 5.03 mg/L; Number of animals: 5; Number of deaths: 0
Female: .78 mg/L; Number of animals: 5; Number of deaths: 0
Female: 5.03 mg/L; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: At the concentration of 5.03 mg/l, some excitement was noted during exposure. Slight breathing difficulty (males and females) and piloerection (males only) were noted just after exposure.
Gross pathology:
Effects on organs:
No abnormal observations were made in any animals of any groups.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute 4-hour inhalation toxicity of TETRABENZYLTHIURAM DISULFIDE in rats of both sexes observed over a period of 15 days was estimated to be: Greater than 5.03 mg/L air