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EC number: 404-310-0 | CAS number: 10591-85-2 PERKACIT TBZTD; PERKACIT TBZTD PDR; PERKACIT TBZTD PDR-D; TBZD
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
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- Nanomaterial pour density
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- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 23, 1987 to March 24, 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Guideline study performed in compliance with GLP, available as unpublished report, no restrictions, fully adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 84/449/EEC, Annex V, B.5
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tetrakis(phenylmethyl)thioperoxydi(carbothioamide)
- EC Number:
- 404-310-0
- EC Name:
- Tetrakis(phenylmethyl)thioperoxydi(carbothioamide)
- Cas Number:
- 10591-85-2
- Molecular formula:
- C30H28N2S4
- IUPAC Name:
- N,N-dibenzyl[(dibenzylcarbamothioyl)disulfanyl]carbothioamide
Constituent 1
- Specific details on test material used for the study:
- Nature of substance: creamy powder
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Albino rabbit, New Zealand White, female
Test system
- Controls:
- other: The untreated eye was used as a control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 30 +/+ 2 mg
VEHICLE
- No vehicle - Duration of treatment / exposure:
- 72 hours
- Observation period (in vivo):
- 16 days
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: Day 1: redness score 3 for nictating membrane; day 7: redness score 1 only for eyelids.
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Day 2 & 3: redness score only for nictating membrane
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 16 days
- Irritation parameter:
- conjunctivae score
- Remarks:
- (discharge)
- Basis:
- animal: #1, #2, and #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1, #2, and #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1, #2, and #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- animal: #1, #2, and #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritant / corrosive response data:
- Reversibility of any observed effect: Changes fully reversible within 16 days
Reversibility of any observed effect: Changes not fully reversible within 14 days - Other effects:
- Maximum scores were recorded for conjunctival redness (2) and chemosis (1) at one hour after treatment.
Any other information on results incl. tables
Instillation of the test substance into one of the eyes of each of three albino rabbits affected the iris and the conjunctivae.
Approximately 70 minutes after exposure animals #1 and #2 showed slight and animal #3 diffuse conjunctival redness. Animal #1 also
showed iridial injection temporary, as well as slight chemosis, which was observed in all three rabbits. The slight conjunctival redness
noted had resolved in animal #2 by day 7, in animal #1 by day 14 and in animal #3 by day 16.
Treatment of the eye with fluorescein approximately 24 hours after test substance instillation showed no corneal epithelial damage in
any of the rabbits. Only animal #1 showed at the first observation slight lacrimation.
No signs of systemic intoxication were observed in any of the rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the estimated Draize score of 7.0 (70 minutes) the test substance should be classified as mildly irritating according to the scheme of Kay and Calandra.
According to the EEC criteria for classification and labelling of dangerous substances, the test substance does not need to be labelled as an eye irritant. - Executive summary:
Tetrabenzylthiuram disulfide (TBzTD) was tested in the rabbit acute eye irritation/corrosion test.
Instillation of approximately 30 mg of the test substance in one of the eyes of each of three albino rabbits resulted in adverse effects on the conjunctivae only.
Approximately 70 minutes after exposure all animals showed slight to diffuse conjunctival redness and slight chemosis and one animal
showed iridial injection. The injection of the iris and the chemosis had resolved within 24 hours. The conjunctival redness resolved between days 7 and 16.
Based on the estimated Draize score of 7.0 (70 minutes) the test substance should be classified as mildly irritating according to
the scheme of Kay and Calandra.
According to the criteria laid down in Annex VI of the EEC Council Directive 67/548/EEC TBzTD does not need to be labelled as an eye irritant.
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