Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-565-9 | CAS number: 142-84-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23. Sep 1969 - 26. Sep 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- BASF-Test, see details in remarks on material and methods.
- GLP compliance:
- no
Test material
- Reference substance name:
- Dipropylamine
- EC Number:
- 205-565-9
- EC Name:
- Dipropylamine
- Cas Number:
- 142-84-7
- Molecular formula:
- C6H15N
- IUPAC Name:
- dipropylamine
- Details on test material:
- - Name of test material (as cited in study report): di-n-propylamine
- Physical state: liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Russians
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.7 and 3.0 kg
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50 µl - Duration of treatment / exposure:
- single application, eyes were not washed out.
- Observation period (in vivo):
- 3 days
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
Results
- Irritation parameter:
- cornea opacity score
- Remarks:
- ; corrosion
- Basis:
- mean
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
Any other information on results incl. tables
The application of the test substance caused after 10 minutes severe corrosion predominantly expressed by severe corneal opacity. Therefor a precise evaluation of erythema, chemosis and iritis scores was not possible. Due to severe effects the test was terminated after 72 h. Severe corneal opacity is considered to be an irreversible effect to ophthalmic tissue.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
