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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Study initiation date: 2021-02-18
Study completion date: 2021-06-10
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
European Parliament and Council, Method A.6 Water solubility (Annex to Regulation
(EC) No 440/2008)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Specific details on test material used for the study:
Date of receipt: 2021-01-12
Expiry date: 2021-07-12
Key result
Water solubility:
0.062 g/L
Conc. based on:
test mat. (dissolved fraction)
Loading of aqueous phase:
345 mg/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
>= 7.3 - <= 8
Details on results:
For details on results, please see the illustration attached to this endpoint study record.
Conclusions:
Water solubility of o-Chlortoluol at 20 °C (OECD 105): 0.062 g/L
Executive summary:

The water solubility of the test item o-Chlortoluol in demineralized water was determined compliant with GLP with the shake flask method at 20 °C according to OECD Guideline
105 (1995). The concentration of the test item in the aqueous phase was determined by HPLC
analysis with UV detection.
Result:
Water solubility of o-Chlortoluol at 20 °C: 0.062 g/L (Currenta, 2021)

Description of key information

Water solubility of o-Chlortoluol at 20 °C (OECD 105): 0.062 g/L

Key value for chemical safety assessment

Water solubility:
62 mg/L
at the temperature of:
20 °C

Additional information

In the reliable and relevant key study, the water solubility of the test item o-Chlortoluol in demineralized water was determined compliant with GLP with the shake flask method at 20 °C according to OECD Guideline 105 (1995). The concentration of the test item in the aqueous phase was determined by HPLC analysis with UV detection.
Result:
Water solubility of o-Chlortoluol at 20 °C: 0.062 g/L (Currenta, 2021)


This result is supported by older data:
Based on a reliable (with restrictions) experimental study lacking detailed experimental documentation (Bayer AG, 1987) the water solubility of 1-chloro-2-methylbenzene was determined following a simplified flask method. Determination was performed by HPLC after 3 to 4 days of stirring. The result is based on fourfold determinations.
Resulting solubility in water of 2-chlorotoluene: 47 mg/l at 20 °C.


In addition, the water solubility of 2-chlorotoluene is reported in the Chemsafe database (accessed Dec. 2020) maintained by PTB (Physikalisch-Technische Bundesanstalt, Braunschweig, Germany), BAM (Bundesanstalt für Materialforschung und –prüfung, Berlin) and DECHEMA (Frankfurt am Main, Germany). Data from PTB (Braunschweig) and BAM (Berlin) must be regarded as reliable chemical safety data. The data set on water solubility for 2-chlorotoluene is marked as "recommended" and verified in terms of reliability and data quality. Information on data origin is made available (data on water solubility from June 2009). Accordingly, the data are reliable.
Water solubility (Chemsafe, Dechema) of 2-chlorotoluene: 50 mg/L at 20 °C


In conclusion, the available relevant older data on water solubility are only slightly below the value determined in the GLP key study by Currenta (2021) and thus in support of this study.