Registration Dossier

Administrative data

Endpoint:
neurotoxicity: inhalation
Remarks:
other: single application
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: special investigation

Data source

Reference
Reference Type:
publication
Title:
Effets depresseurs de produits chimiques sur le systeme nerveux central
Author:
De Ceaurriz J, Bonnet P, Certin C, Muller J, Guenier JP
Year:
1981
Bibliographic source:
Cahiers de Notes Documentaires No. 104, 351-355

Materials and methods

Principles of method if other than guideline:
measurement of the increase in the seizure threshold in mcie for the onset of clonic convulsions induced by i.v. administration of pentetrazole; the concentration in air causing a 50 % increase in the seizure threshold (STI 50) was determined
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
purity 98%, supplier: Aldrich

Test animals

Species:
mouse
Strain:
Swiss
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Vehicle:
air
Analytical verification of doses or concentrations:
yes
Duration of treatment / exposure:
no data
Frequency of treatment:
single exposure
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels

Dose descriptor:
other: STI
Effect level:
4.062 mg/L air
Based on:
test mat.
Sex:
male
Remarks on result:
other:

Any other information on results incl. tables

study on the central nervous system depressant effects:
short-term exposure (exposure time unspecified) of mice to vapours of o-chlorotoluene increased the threshold for
the onset of clonic convulsions induced by i.v. administration of pentetrazole; the concentration in air causing
a 50 % increase in the seizure threshold (STI 50) was determined to be 773 ppm (= ca. 4.062 mg o-chlorotoluene/l)

Applicant's summary and conclusion

Executive summary:
short-term exposure (exposure time unspecified) of mice to vapours of o-chlorotoluene increased the threshold for
the onset of clonic convulsions induced by i.v. administration of pentetrazole; the concentration in air causing
a 50 % increase in the seizure threshold (STI 50) was determined to be 773 ppm (= ca. 4.062 mg o-chlorotoluene/l)