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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
neurotoxicity: inhalation
Remarks:
other: single application
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
publication
Title:
Effets depresseurs de produits chimiques sur le systeme nerveux central
Author:
De Ceaurriz J, Bonnet P, Certin C, Muller J, Guenier JP
Year:
1981
Bibliographic source:
Cahiers de Notes Documentaires No. 104, 351-355

Materials and methods

Principles of method if other than guideline:
Measurement of the increase in the seizure threshold in mice for the onset of clonic convulsions induced by i.v. administration of pentetrazole; the concentration in air causing a 50 % increase in the seizure threshold (STI 50) was determined.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chlorotoluene
EC Number:
202-424-3
EC Name:
2-chlorotoluene
Cas Number:
95-49-8
Molecular formula:
C7H7Cl
IUPAC Name:
1-chloro-2-methylbenzene
Details on test material:
purity 98%, supplier: Aldrich

Test animals

Species:
mouse
Strain:
Swiss
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Vehicle:
air
Analytical verification of doses or concentrations:
yes
Duration of treatment / exposure:
no data
Frequency of treatment:
single exposure
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels

Dose descriptor:
other: STI
Effect level:
4.062 mg/L air
Based on:
test mat.
Sex:
male
Remarks on result:
other:

Any other information on results incl. tables

Study on the central nervous system depressant effects:
Short-term exposure (exposure time unspecified) of mice to vapours of  o-chlorotoluene increased the threshold for the onset of clonic convulsions induced by i.v. administration of pentetrazole; the concentration in air causing a 50 % increase in the seizure threshold (STI 50) was determined to be 773 ppm (= ca. 4.062 mg o-chlorotoluene/l).

Applicant's summary and conclusion

Executive summary:

Short-term exposure (exposure time unspecified) of mice to vapours of o-chlorotoluene increased the threshold for the onset of clonic convulsions induced by i.v. administration of pentetrazole; the concentration in air causing a 50% increase in the seizure threshold (STI 50) was determined to be 773 ppm (= ca. 4.062 mg o-chlorotoluene/l)