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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

Currently viewing:

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Documentation of the threshold limit values and biological exposure indicies
Author:
Ely TS
Year:
1991
Bibliographic source:
personal communication, cited in ACGIH Documentation of Threshold Limit Values, 6th edition, p. 308 (1991)

Materials and methods

Type of study / information:
acute oral toxicity
Principles of method if other than guideline:
undiluted o-chlorotoluene was administered orally to rats in doses ranging from 50-1600 mg/kg

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chlorotoluene
EC Number:
202-424-3
EC Name:
2-chlorotoluene
Cas Number:
95-49-8
Molecular formula:
C7H7Cl
IUPAC Name:
1-chloro-2-methylbenzene
Details on test material:
no data

Results and discussion

Any other information on results incl. tables

o-chlorotoluene (undiluted material) has been administered
orally to rats in doses ranging from 50-1600 mg/kg bw; mo-
derate to marked weakness was noted and vasodilatation was
produced at the higher dose levels; all rats survived and
were gaining weight 2 w later (no further data)

Applicant's summary and conclusion

Executive summary:

The oral LD50 is > 1600 mg/kg