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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well conducted and sufficient documented

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Unnamed
Year:
1974
Reference Type:
publication
Title:
The metabolism of 14C o-chlorotoluene in the rat
Author:
Wold JS, Emmerson JL
Year:
1974
Bibliographic source:
The Pharmacologist 16, 196

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
uniformly ring-labeled 14C o-chlorotoluene was administered by gavage to rats at a dose of 320 mg/kg bw. Expired air, urine and faeces were examined for metabolites.
GLP compliance:
not specified

Test material

1
Chemical structure
Reference substance name:
2-chlorotoluene
EC Number:
202-424-3
EC Name:
2-chlorotoluene
Cas Number:
95-49-8
Molecular formula:
C7H7Cl
IUPAC Name:
1-chloro-2-methylbenzene
Test material form:
liquid
Radiolabelling:
yes

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Duration and frequency of treatment / exposure:
single application
Doses / concentrations
Remarks:
Doses / Concentrations:
320 mg/kg bw
No. of animals per sex per dose / concentration:
no data
Control animals:
not specified

Results and discussion

Preliminary studies:
no data

Toxicokinetic / pharmacokinetic studies

Details on absorption:
no data
Details on distribution in tissues:
no data
Details on excretion:
The recovery of radioactivity at 48 h averaged 11% in the expired air, 81% in urine, and 4% in feces; radioactivity in expired air was identified as unchanged o-chlorotoluene; urinary metabolites (as % of dose) were: o-chlorohippuric acid (16 - 20%), a mercapturic acid conjugate of o-chlorotoluene (20 - 24%) and polar metabolites (36 - 43%); enzymatic hydrolysis of rat urine indicated that the polar metabolites included the glucuronide conjugate of the phenolic hydroxylation product of o-chlorotoluene; unchanged o-chlorotoluene was not present in urine or feces of treated rats.

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
o-chlorohippuric acid, mercapturic acid conjugate of o-chlorotoluene, glucuronide conjugate of the phenolic hydroxylation product of o-chlorotoluene

Any other information on results incl. tables

Unchanged o-chlorotoluene was not present in urine or feces of treated rats.

Applicant's summary and conclusion

Executive summary:

Uniformly ring-labeled 14C o-chlorotoluene was administered by gavage to rats at a dose of 320 mg/kg bw. Expired air, urine and faeces were examined for metabolites.

The recovery of radioactivity at 48 h averaged 11% in the expired air, 81% in urine, and 4% in feces; radioactivity in expired air was identified as unchanged o-chlorotoluene; urinary metabolites (as % of dose) were: o-chlorohippuric acid (16  - 20%), a mercapturic acid conjugate of o-chlorotoluene (20 - 24%) and polar metabolites (36 - 43%); enzymatic hydrolysis of rat urine indicated that the polar metabolites included the glucuronide conjugate of the phenolic hydroxylation product of o-chlorotoluene; unchanged o-chlorotoluene was not present in urine or feces of treated rats.