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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well documented and scientifically acceptable

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972
Report Date:
1981

Materials and methods

Principles of method if other than guideline:
10 rats were exposed at various nominal concentrations: 3471, 6402, 8406, 8819 ppm to o-chlorotoluene, observation period: 14 d, calculated LC50
GLP compliance:
no
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
purity: > 98 %

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
3471, 6402, 8406, 8819 ppm = ca. 18.29, 33.73, 44.30, 46.47 mg/l
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
7 119 ppm
Exp. duration:
4 h

Any other information on results incl. tables

LC50 value: 7119 (6131-8266) ppm = ca. 37.517 mg/l
clinical signs:
during exposure: hypoactivity, dyspnea, abdominal
respiration, exudation from eyes and nose, tremors and
prostration, duration: 2-4 days
at necropsy: uneven coloration on the surface of the lungs
and liver and foci of red and black discoloration on the
surface of the lungs.

Applicant's summary and conclusion

Executive summary:

10 male rats were exposed whole body to 3471, 6402, 8406, 8819 ppm = ca. 18.29, 33.73, 44.30, 46.47 mg/l for 4 hours. clinical signs and mortality were recorded during the exposure and a 14 d post observation period and a necropsy was performed.

LC50 = 7719 ppm (ca. 37.517 mg/l), male rats