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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well documented and scientifically acceptable

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972
Report date:
1981

Materials and methods

Principles of method if other than guideline:
10 rats were exposed at various nominal concentrations: 3471, 6402, 8406, 8819 ppm to o-chlorotoluene, observation period: 14 d, calculated LC50
GLP compliance:
no
Test type:
standard acute method

Test material

1
Chemical structure
Reference substance name:
2-chlorotoluene
EC Number:
202-424-3
EC Name:
2-chlorotoluene
Cas Number:
95-49-8
Molecular formula:
C7H7Cl
IUPAC Name:
1-chloro-2-methylbenzene
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
3471, 6402, 8406, 8819 ppm = ca. 18.29, 33.73, 44.30, 46.47 mg/l
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
7 119 ppm
Exp. duration:
4 h

Any other information on results incl. tables

LC50 value: 7119 (6131-8266) ppm = ca. 37.517 mg/l
clinical signs:
during exposure: hypoactivity, dyspnea, abdominal respiration, exudation from eyes and nose, tremors and prostration, duration: 2-4 days at necropsy: uneven coloration on the surface of the lungs and liver and foci of red and black discoloration on the surface of the lungs.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Ten male rats were exposed whole body to 3471, 6402, 8406, 8819 ppm = ca. 18.29, 33.73, 44.30, 46.47 mg/l for 4 hours. Clinical signs and mortality were recorded during the exposure and a 14 d post observation period. A necropsy was performed. The LC50 value was 7119 ppm (ca. 37.517 mg/l).
Executive summary:

Ten male rats were exposed whole body to 3471, 6402, 8406, 8819 ppm = ca. 18.29, 33.73, 44.30, 46.47 mg/l for 4 hours. Clinical signs and mortality were recorded during the exposure and a 14 d post observation period. A necropsy was performed. The LC50 value was 7119 ppm (ca. 37.517 mg/l).