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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: careful observations reported but LD50 value was not reached

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report Date:
1976

Materials and methods

Principles of method if other than guideline:
5 rats/sex, hairs removed from the trunk, chemical applied to this prepared area of the skin, single application of 1 ml/kg for 24 hours, during exposure covered with plaster backed with aluminium foil
GLP compliance:
no
Test type:
other: single dose: 1ml/kg bw for 24 hours

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
purity: technical pure

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 hours
Doses:
1 ml/kg bw = 1.08 g/cm³ (density = 1.08 g/cm according LXS MSDS)
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 1 080 mg/kg bw

Any other information on results incl. tables

immediately after the application, the animals showed excitation obviously 
induced by pain and lasting for up to 2 h;
within 24 h difficulty of breathing occurred;
the general condition of the animals was reduced up to 8 d after administration
of the test substance; no deaths occurred;
after 24 h, the treated areas of skin showed no signs of irritation

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information
Executive summary:

method: 5 rats/sex, hairs removed from the trunk, chemical applied to this prepared area of the skin, single application of 1 ml/kg for 24 hours, during exposure covered with plaster backed with aluminium foil

result: LD50 > 1.08 mg/kg bw (rat); no death occured, immediately after application the animals showed excitation for 2 hours, within 24 h difficulty of breathing occured. The general condition of the animals was reduced up to 8 d after administration of the test substance.