Registration Dossier

Toxicological information

Repeated dose toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: description of the method used is too short to be taken into account

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1970
Report Date:
1979

Materials and methods

Principles of method if other than guideline:
Groups of 4 male and four female rats (150 - 170 g bw) were exposed to atmospheres of o-chlorotoluene (500, 1000 or 40000 ppm (= ca. 2.635, 5.27 or 210.8 mg/l) 6 hours/days, 5 days/week for 3 weeks.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
purity. no data

Test animals

Species:
rat
Strain:
other: young adult Alderly Park strain
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
air
Remarks on MMAD:
MMAD / GSD: no data
Duration of treatment / exposure:
3 w
Frequency of treatment:
6 h/d, 5 d/w
Doses / concentrations
Remarks:
Doses / Concentrations:
500, 1000 or 40000 ppm (= ca. 2.635, 5.27 or 210.8 mg/l)
Basis:

No. of animals per sex per dose:
4 males and 4 females
Control animals:
not specified
Details on study design:
Post-exposure period: no

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
ca. 500 ppm
Sex:
male/female

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

500 ppm: no toxic effects
1000 ppm:
lethargy, diminished response to noise, traces of blood around the nostrils, low body weight gain;
no changes were found when the blood taken 24 h after the
cessation of exposure and the final 24-h urine were analysed;
no significant autopsy findings;
histopathological findings:
some foamy macrophages observable free in the alveoli
40000 ppm: death of all the exposed animals within 3 minutes

Applicant's summary and conclusion

Executive summary:

Groups of 4 male and four female rats (150 - 170 g bw) were exposed to atmospheres of o-chlorotoluene (500, 1000 or 40000 ppm (= ca. 2.635, 5.27 or 210.8 mg/l) 6 hours/days, 5 days/week for 3 weeks. Exposure to an atmosphere of 500 ppm (ca. 2.635 mg/l) was without effect.

the NOEL is therefore 500 ppm.