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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Toxicity to reproduction

Currently viewing:

Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: effects on spermatogenesis
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: speramtogenesis was examined in an acute toxicity study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970

Materials and methods

Principles of method if other than guideline:
3 males/dose, pathological examination of the survivors
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chlorotoluene
EC Number:
202-424-3
EC Name:
2-chlorotoluene
Cas Number:
95-49-8
Molecular formula:
C7H7Cl
IUPAC Name:
1-chloro-2-methylbenzene
Details on test material:
purity: no data, diluted in an inert dispersing medium

Test animals

Species:
rat
Strain:
other: Alderley Park
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on mating procedure:
not applicable -
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
Exposure period: single administration
Duration of test: 7 days
Frequency of treatment:
single treatment
Details on study schedule:
survivors were observed for 7 days when they were killed for pathological examination
Doses / concentrations
Remarks:
Doses / Concentrations:
10800, 5420, 2700 mg/kg bw
Basis:
nominal conc.
No. of animals per sex per dose:
3 animals
Control animals:
not specified

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

Dose descriptor:
NOAEL
Remarks on result:
not determinable
Remarks:
no NOAEL identified Generation not specified (migrated information)

Overall reproductive toxicity

Reproductive effects observed:
not specified

Any other information on results incl. tables

Mortality: high dose: 3/3, middle dose: 2/3, low dose: 0/3; microscopically all the survivors showed a reduction in spermatogenesis (no further data).

Applicant's summary and conclusion

Executive summary:

Groups of 3 male rats were given one dose of 10.8, 5.42 or 2.7 g/kg bw by stomach tube and the survivors observed for 7 days when they were killed for pathological examination. Microscopically all the males showed a reduction in spermatogenesis.