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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Pre-GLP, pre-guideline study according to acceptable principles similar to those of OECD TG

Data source

Reference
Reference Type:
publication
Title:
Monographs on Fragrance Raw Materials
Author:
Moreno OM
Year:
1977
Bibliographic source:
Food and Cosmetics Toxicology 17 (Supplement), 715-722

Materials and methods

Principles of method if other than guideline:
The substance was applied to the skin of rabbits
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Reference substance name:
Benzoic acid
EC Number:
200-618-2
EC Name:
Benzoic acid
Cas Number:
65-85-0
IUPAC Name:
benzoic acid
Details on test material:
The test material was benzoic acid. Methyl benzoate is hydrolysed to benzoic acid and methanol in vivo and read across from benzoic acid therefore is applicable (see justification document in section 13).

Test animals

Species:
rat
Sex:
male/female

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance benzoic acid was not acutely toxic after a single application to the skin of rabbits at a dose of 5000 mg/kg body weight.
Executive summary:

The acute dermal toxicity of the substance benzoic acid was tested with rabbits by applying a single dermal dose. The LD50 value was greater than 5000 mg/kg body weight. Please see read-across justification (section 13).