Registration Dossier

Administrative data

Description of key information

The registration item is not irritating to the skin and eyes.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation / corrosion

Key study

Methyl benzoate is considered to be not irritating to skin. The result from fully reliable study conducted according to OECD TG 404 showed no evidence of primary cutaneous irritation throughout the observation period of 72 hours.

Eye irritation / corrosion

Key study

The result from fully reliable study conducted according to OECD TG 405 showed only slight irritation effects 24 hours after the treatment that consisted mainly of redness of the conjunctivae (all three animals) and weak chemosis (two out of three animals). All effects had disappeared after 72 hours. Therefore methyl benzoate is considered to be not irritating to eye.


Justification for selection of skin irritation / corrosion endpoint:
The full reliable study performed according to principles equivalent to those of OECD TG was chosen as key study.

Justification for selection of eye irritation endpoint:
Only one valid and reliable stud is available.

Justification for classification or non-classification

- skin irritation/corrosion:

Based on the above stated assessment of the irritating properties of methyl benzoate, the results from reliable studies show that the substance is not irritating to the skin. Accordingly methyl benzoate does not need to be classified according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and according to CLP (Regulation (EC) No 1272/2008 of the European Parliament and of the Council) as implementation of UN-GHS in the EU.

 

- eye irritation/corrosion:

Based on the above stated assessment of the irritating properties of methyl benzoate, the results from a reliable study shows that the substance is not corrosive or irritating to the eye. Accordingly the substance does not need to be classified according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and according to CLP (Regulation (EC) No 1272/2008 of the European Parliament and of the Council) as implementation of UN GHS in the EU.