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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-epoxybutane
EC Number:
203-438-2
EC Name:
1,2-epoxybutane
Cas Number:
106-88-7
Molecular formula:
C4H8O
IUPAC Name:
oxolane
Test material form:
liquid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: BASF SE
- Age at study initiation: no data
- Weight at study initiation: The mean body weight of male animals was 206 g, the mean body weight of female animals was 174 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
CMC (carboxymethyl cellulose)
Details on oral exposure:
The test substance was given as an emulsion in 0.5% aqueous CMC solution.
Observation period: 7 resp. 14 days
Doses:
100, 464, 681, 1000, 1210, 1470, 1780, 2150, 4640, 10000 µL/kg
No. of animals per sex per dose:
5 and/or 10 (see mortality table)
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 resp. 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Statistics:
no data

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
male/female
Dose descriptor:
approximate LD50
Effect level:
ca. 913 mg/kg bw
Remarks on result:
other: Calculated with density of 0.83 g/cm3
Sex:
male/female
Dose descriptor:
approximate LD50
Effect level:
ca. 1 100 other: µL/kg
Remarks on result:
other: original value
Mortality:
yes (see table below)
Clinical signs:
other: slight apathy, partially staggering, dyspnoea, diarrheic feces, exsiccosis, abdominal and lateral position
Gross pathology:
acute heart dilatation (both sides), acute congestive hyperemia, intra-abdominal adhesions of the stomach, thickened wall of the forestomach, partially formation of diverticulum

Any other information on results incl. tables

Mortality:





























































































































































































































 Dose (µL/kg) Concentration (%) No. of animals dead within            
    1 hour 24 hours48 hours 7 days 14 days
 10000 35 5 males 0/5 5/5 5/5 5/5 
   5 females 0/5 5/5 5/5 5/5 
 4640 35 5 males 0/5 5/5 5/5 5/5 
   5 females 0/5 5/5 5/5 5/5 
 2150 30 10 males 0/10 10/10 10/10 10/10 
   10 females 1/10 10/10 10/10 10/10 
 1780 15 5 males 0/5 5/5 5/5 5/5 
   5 females 0/5 5/5 5/5 5/5 
 1470 15 10 males 0/10 10/10 10/10 10/10 
   10 females 0/10 10/10 10/10 10/10 
 1210 15 5 males 0/5 2/5 2/5 2/5 
   5 females 0/5 5/5 5/5 5/5 
 1000 15 5 males 0/5 1/5 1/5 1/5 
   5 females 0/5 0/5 0/5 0/5 
 681 6 5 males 0/5 0/5 0/5 0/5 
   5 females 0/5 0/5 0/5 0/5 
 464 6 5 males 0/5 0/5 0/5 0/5 
   5 females 0/5 0/5 0/5 0/5 
 100 1.5 5 males 0/5 0/5 0/5 0/5 0/5
   5 females 0/5 0/5 0/5 0/5 0/5

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria