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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1953
Report date:
1953

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
In this study a rabbit received repeated exposures upon the abdomen to a 1% solution.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-epoxybutane
EC Number:
203-438-2
EC Name:
1,2-epoxybutane
Cas Number:
106-88-7
Molecular formula:
C4H8O
IUPAC Name:
oxolane
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Type of coverage:
not specified
Vehicle:
other: report states a 1% solution but doesn't identify the vehicle
Details on dermal exposure:
A rabbit received repeated exposures upon the abdomen to a 1% solution.
Duration of exposure:
no data
Doses:
1% solution
No. of animals per sex per dose:
no data
Control animals:
no

Results and discussion

Effect levels
Dose descriptor:
LD50
Remarks on result:
not determinable because of methodological limitations

Any other information on results incl. tables

Butylene Oxide does not present a problem from skin absorption under ordinary handling conditions. However, prolonged exposure to relatively large areas of skin may result in the absorption of toxic amounts.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification