Registration Dossier
Registration Dossier
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EC number: 205-746-2 | CAS number: 149-74-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- No guideline is specified and only limited details of the method are given in this brief report.
- GLP compliance:
- no
Test material
- Reference substance name:
- Dichloro(methyl)(phenyl)silane
- EC Number:
- 205-746-2
- EC Name:
- Dichloro(methyl)(phenyl)silane
- Cas Number:
- 149-74-6
- Molecular formula:
- C7H8Cl2Si
- IUPAC Name:
- dichloro(methyl)(phenyl)silane
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- no details
- Observation period (in vivo):
- no details
- Number of animals or in vitro replicates:
- no details
Results and discussion
In vivo
Results
- Irritation parameter:
- other: severe pain and tissue damage
- Time point:
- other: not stated
Any other information on results incl. tables
Application of an unspecified volume of the neat material caused severe pain and tissue damage resulting in loss of both eyes. The eyes were washed and unwashed, no difference is recorded as to the effect of this treatment.
Applicant's summary and conclusion
- Conclusions:
- A brief report of a possibly limited study found that the neat material (volume unspecified) applied to rabbit eyes caused severe pain and tissue damage resulting in the loss of both eyes.
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