Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

Aquatic bioaccumulation

4,4’-Methylenedicyclohexyl diisocyanate is characterized by a BCF of 10186 being calculated with BCFWIN v. 2.17 (Currenta, 2009a). However, the direct and indirect exposure of aquatic organisms is unlikely because 4,4’-methylenedicyclohexyl diisocyanate hydrolysis rapidly in water within 2 hours (half-life 1.97 hours).

The hydrolysis product of 4,4’-methylenedicyclohexyl diisocyanate with a calculated bioconcentration factor of 7.3 does not have a high bioaccumulation potential (Currenta, 2009b).

The following information is taken into account for any hazard / risk / bioaccumulation assessment:

4,4'-Methylenedicyclohexyl diisocyanate hydrolyses rapidly in the presence of water with a half life of approximately 2 hours. Therefore a risk estimation regarding the bioaccumulation potential of 4,4'methylenedicyclohexyl diisocyanate on the basis of a log Kow or a BCF, determined by QSAR, is misleading. A calculated theoretical log Kow or BCF value reflects the undissociated and unreacted molecule without influence of water.

However, the substance is not persistent in water due to the rapid hydrolysis. Therefore it is not bio-available. Possible hydrolysis products are less lipophilic. On the basis of these information it can be expected that relevant bioaccumulation of 4,4'-methylenedicyclohexyl diisocyanate does not occur.

Terrestrial bioaccumulation

Not applicable.

Secondary poisoning

Because of the rapid hydrolysis of 4,4'-methylenedicyclohexyl diisocyanate in water, it is not expected that this substance will bioconcentrate in aquatic organisms, or bioaccumulate in the food chain. No information on BCFs and food chain bioaccumulation could be found for 4,4'-methylenedicyclohexyl diisocyanate in the available literature; however, a BCF of approximately 7 was calculated for the hydrolysis product 4,4’-methylenedicyclohexyl diamine (CAS number 1761-71-3) which indicates a very low bioaccumulation potential. For this reason, there is no risk for secondary poisoning. It is not required to carry out a risk characterisation for secondary poisoning.