Registration Dossier
Registration Dossier
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EC number: 204-399-4 | CAS number: 120-47-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- not specified
- Remarks:
- Publication supporting read-across and providing toxicokinetic data
- Adequacy of study:
- supporting study
Data source
Reference
- Reference Type:
- publication
- Title:
- Application of grouping and read‑across for the evaluation of parabens of different chain lengths with a particular focus on endocrine properties
- Author:
- Susann Fayyaz, Reinhard Kreiling, Ursula G. Sauer
- Year:
- 2 021
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Executive summary:
The in vivo toxicokinetic screening studies consistently showed that Methyl, ethyl and propyl paraben were taken up systemically very rapidly after oral gavage administration to rats and that they were eliminated very rapidly from the bloodstream within one hour after administration. Also, for all test items, the major metabolite p-hydroxybenzoic acid was cleared rapidly from the blood stream within 4–8 h. P-hydroxybenzoic acid does not exhibit systemic toxicity or DART, and it is also not endocrine active.
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