Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 938-989-4 | CAS number: -
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary source. For justification of read-across see CSR chapter 1.3.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Dermal exposure assessment: principles and applications
- Author:
- US EPA, Exposure Assessment Group
- Year:
- 1 992
- Bibliographic source:
- EPA/600/8-91/011B, Interim Report
- Reference Type:
- secondary source
- Title:
- HERAG (health risk assessment for metals) Assessment of occupational dermal exposure and dermal absorption for metals and inorganic metal compounds
- Author:
- EBRC Consulting GmbH
- Year:
- 2 007
- Bibliographic source:
- HERAG Fact Sheet 01, 2007
Materials and methods
- Principles of method if other than guideline:
- no guideline followed.
- GLP compliance:
- no
Test material
- Reference substance name:
- inorganic substances
- IUPAC Name:
- inorganic substances
- Test material form:
- not specified
- Details on test material:
- no data
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: no aimals tested
- Strain:
- other: no aimals tested
Administration / exposure
- Type of coverage:
- other: no aimals tested
- Vehicle:
- other: no aimals tested
- Duration of exposure:
- no aimals tested
- Doses:
- no aimals tested
- No. of animals per group:
- no aimals tested
Results and discussion
Percutaneous absorption
- Remarks on result:
- other:
- Conversion factor human vs. animal skin:
- no animals tested
Any other information on results incl. tables
According to the EPA report on dermal exposure, most inorganics have Kp values (permeability coefficient for chemical from an unspecified vehicle through the skin) near 10-3cm/hour (substantially lower than those of most organic compounds) and a few even lower values are observed for inorganic substances. Accordingly, a default assumption of 10-3cm/hour is recommended by US EPA for inorganics that have not been tested.
In the HERAG fact sheet prepared by EBRC Consulting GmbH default dermal absorption factors for metal cations of maximal 1% are proposed.
Applicant's summary and conclusion
- Conclusions:
- Dermal absorption of inorganics is assumed to be below 10 %.
- Executive summary:
- According to the EPA report on dermal exposure, Kp values (permeability coefficient for chemical from an unspecified vehicle through the skin) near 10 exp-3 cm/hour (substantially lower than those of most organic compounds) and a few even lower values are observed for inorganic substances. Accordingly, a default assumption of 10-3 cm/hour is recommended by US EPA for inorganics that have not been tested (indicating a low level of dermal absorption). Based on this Kp a low absorption rate through the skin can be assumed. Others propose dermal absorption factors for metal cations of maximal 1% for inorganics (HERAG fact sheet). All in all, in a conservative approach dermal absorption of inorganics can be assumed to be < 10 %.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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