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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Sensitisation data (human)

Currently viewing:

Administrative data

Endpoint:
sensitisation data (humans)
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Publication data with only few information

Data source

Reference
Reference Type:
publication
Title:
Allergic contact Dermatitis from cocoamidopropyl betaine, cocamidoamine, 3-(Dimethylamino)propylamine, and oleamidopropyl dimethylamine : Co-reactions or cross- reactions?
Author:
Moreau L. and Sasseville D.
Year:
2004
Bibliographic source:
Dermatitis. 2004 Sep;15(3):146-9

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report

Test material

Constituent 1
Chemical structure
Reference substance name:
(9E)-N-[3-(dimethylamino)propyl]octadec-9-enamide
EC Number:
800-353-8
Cas Number:
1379524-06-7
Molecular formula:
C23H46N2O
IUPAC Name:
(9E)-N-[3-(dimethylamino)propyl]octadec-9-enamide

Results and discussion

Results of examinations:
In this publication, the authors reported different cases of contact dermatitis caused by amido amines derivatives used in cosmetic products. Several experiments (patch-tests) found in literature and discussed in this paper confirm that the presence of 3-dimethylaminopropylamine (a feedstock found as an impurity) could be hypothesized to explain these allergic reactions.

Applicant's summary and conclusion

Executive summary:

In this publication, the authors reported different cases of contact dermatitis caused by amido amines derivatives used in cosmetic products. Several experiments (patch-tests) found in literature and discussed in this paper confirm that the presence of 3-dimethylaminopropylamine (a feedstock found as an impurity) could be hypothesized to explain these allergic reactions.